Journal of Agriculture and Food Science
Journal of Agriculture and Food Science. 2026; 6: (1) ; 10.12208/j.jafs.20260001 .
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内蒙古蒙牛乳业（集团）股份有限公司内蒙古蒙牛乳业（集团）股份有限公司全球研发创新中心 内蒙古呼和浩特;
*通讯作者： 赵晓慧,单位：内蒙古蒙牛乳业（集团）股份有限公司内蒙古蒙牛乳业（集团）股份有限公司全球研发创新中心 内蒙古呼和浩特; ；
本综述系统梳理益生菌制造三阶段工程策略的最新研究进展：上游工程依托基因组学与机器学习技术，实现菌株精准筛选与定向设计；中游工程基于实时传感与智能模型调控，完成发酵过程高效优化；下游工程通过陶瓷膜过滤、电喷雾干燥等新型分离干燥技术，搭配创新型微胶囊壁材，大幅提升益生菌回收率与产品稳定性。展望未来，跨学科技术深度融合将推动益生菌制造领域向数据驱动与精准调控的全新范式加速转变。
This review systematically summarizes the latest research advances in three-stage engineering strategies for probiotic manufacturing. In upstream engineering, genomics and machine learning enable precise screening and rational design of strains. In midstream engineering, efficient optimization of fermentation processes is realized through intelligent control based on real-time sensing and mathematical models. In downstream engineering, novel separation and drying technologies such as ceramic membrane filtration and electrospray drying, in combination with innovative microcapsule wall materials, markedly improve the recovery rate and stability of probiotics. Looking ahead, in-depth integration of interdisciplinary technologies will drive the probiotic manufacturing field to accelerate its transformation to a data-driven and precision-regulated paradigm.
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