Clinical observation of patient-controlled analgesia with hydromorphone versus subcutaneous injection ofmorphine in the treatment of burst pain
氢吗啡酮自控镇痛对比吗啡皮下注射治疗爆发痛的临床观察

摘要

目的 探讨氢吗啡酮自控镇痛对比吗啡治疗爆发痛的临床效果。方法 将我院2020年3月至2022年3月的60例爆发痛患者，随机分组，吗啡组给予口服吗啡缓释片进行镇痛，氢吗啡酮组进行了氢吗啡酮自控镇痛。比较效果和不良反应。结果 氢吗啡酮组给药后15min，30min，1h，4h，12h，24h，48h，72h爆发痛发生次数低于吗啡组，P＜0.05。氢吗啡酮组给药后15min，30min，1h，4h，12h，24h，48h，72h镇痛评分VAS分值低于吗啡组，P＜0.05。氢吗啡酮组给药后24h和72h的生活质量高于吗啡组，P＜0.05。氢吗啡酮组嗜睡、恶心呕吐、瘙痒等的发生率低于吗啡组，P＜0.05。结论 爆发痛患者实施氢吗啡酮自控镇痛效果确切，可有效缓解疼痛，且安全性高，可减少嗜睡、恶心呕吐、瘙痒等的出现，是一种值得推广的方法。

Abstract

Objective To investigate the clinical effect of hydromorphone patient-controlled analgesia compared with morphine in the treatment of burst pain.
Methods 60 patients with burst pain in our hospital from March 2020 to March 2022 were randomly divided into groups. The morphine group was given oral morphine sustained-release tablets for analgesia, and the hydromorphone group was given hydromorphone-controlled analgesia. Compare effects and adverse effects.
Results The frequency of burst pain in the hydromorphone group was lower than that in the morphine group at 15min, 30min, 1h, 4h, 12h, 24h, 48h, and 72h after administration, P<0.05. The VAS scores of the hydromorphone group were lower than those of the morphine group at 15min, 30min, 1h, 4h, 12h, 24h, 48h, and 72h after administration, P<0.05. The quality of life in the hydromorphone group at 24h and 72h after administration was higher than that in the morphine group, P<0.05. The incidences of somnolence, nausea, vomiting, and itching in the hydromorphone group were lower than those in the morphine group, P<0.05.
Conclusion   Hydromorphone patient-controlled analgesia is effective in patients with breakout pain, can effectively relieve pain, and has high safety, and can reduce the occurrence of drowsiness, nausea, vomiting, itching, etc.