Observation on the therapeutic effect of quadruple therapy in Helicobacter pylori (HP) infection
四联疗法在幽门螺杆菌（Hp）感染中的治疗效果观察

摘要

目的 幽门螺杆菌(Hp)感染是引起消化系统疾病的主要原因之一，采用四联疗法进行治疗，并分析其应用效果。方法 将2020年1月-2022年3月期间我院及进修学习期间收治的158例幽门螺杆菌(Hp)感染患者随机分为对照组和实验组，各79例，对照组采用三联疗法，实验组为四联疗法，对比应用效果。结果 实验组幽门螺旋杆菌清除率高于对照组，且不良反应发生率低于对照组，对比两组临床症状积分，实验组优于对照组，P＜0.05。结论 四联疗法能够更加高效的清除HP，改善患者的临床症状，对患者的消化道进行保护，可以使不良反应的发生率降低，在患者治疗期间保证安全性，更加快速的缓解患者的临床症状。

Abstract

Objective: Helicobacter pylori (HP) infection is one of the main causes of digestive system diseases. Four combination therapy is used for treatment, and its application effect is analyzed.
Methods: 158 patients with Helicobacter pylori (HP) infection treated in our hospital from January 2020 to December 2021 were randomly divided into control group and experimental group, with 79 cases in each group. The control group was treated with triple therapy and the experimental group was treated with quadruple therapy. The application effects were compared.
Results: the clearance rate of Helicobacter pylori in the experimental group was higher than that in the control group, and the incidence of adverse reactions was lower than that in the control group ，comparing the two groups, the experimental group was better than the control group,(P < 0.05).
Conclusion  : quadruple therapy can remove HP more efficiently, improve patients' clinical symptoms, protect patients' digestive tract, reduce the incidence of adverse reactions, ensure safety during patients' treatment, and alleviate patients' clinical symptoms more quickly.