Analysis of Candida species distribution and drug sensitivity in 58 cases of bloodstream infection
58例血流感染假丝酵母菌菌种分布及药物敏感性分析

摘要

目的 分析我院2019年1月至2021年12月发生血流感染假丝酵母菌的菌种分布及耐药性，为临床预防和治疗假丝酵母菌感染患者提供依据。方法 回顾性分析2019年1月至2021年12月我院血流感染患者假丝酵母菌菌种分布及药物敏感性。结果 2019年至2021年我院血流感染患者假丝酵母菌菌种分离出58株、其中，白色假丝酵母菌21株（36.20%）、近平滑假丝酵母菌17株（29.31%）、光滑假丝酵母菌11（18.97%）株、热带假丝酵母菌9株（15.52%）；药物敏感性试验以两性霉素、制霉菌素、5-氟胞嘧啶药物敏感性最高。结论 我院血流假丝酵母菌感染患者以白色假丝酵母菌感染为主，药物敏感性以对两性霉素、制霉菌素、5-氟胞嘧啶最为敏感，对咪康唑、益康唑、酮康唑全部耐药，其余药物不同菌种，药物明感性存在差异，临床需依据本地区医院血流感染菌种分布及药物敏感性试验，合理选择抗菌药物。

Abstract

Objective To analyze the bacterial distribution and drug resistance of Candida bloodflow infection from January 2019 to December 2021,and to provide a basis for the clinical prevention and treatment of Candida infected patients.
Methods The species distribution and drug sensitivity of Candida species were analyzed from January 2019 to December 2021.
Results From 2019 to 2021,58 strains were isolated from Candida strains, among which,21 Candida albicans (36.20%), 17 Candida near smooth(29.31%),11(18.97%),and 9 Candida tropicalis (15.52%); Amphotericin, nystatin and 5-fluorocytosine were the most sensitive drugs.
Conclusion   Patients in our hospital, the drug susceptibility is most sensitive to amphotericin, nystatin, 5-fluorocytosine, miconazole, Iconazole, ketoconazole, fluconazole, voriconazole, different susceptibility, according to the region, the hospital distribution and drug sensitivity test.