Clinical efficacy and safety of silodosin in the treatment of chronic prostatitis
西洛多辛治疗慢性前列腺炎的临床疗效与安全性

摘要

目的 评估西洛多辛（4mg和8mg）与安慰剂在慢性前列腺炎中的疗效和安全性。方法 选取我院18岁及以上123例慢性前列腺炎患者，这些患者以前未接受过治疗。将这些患者分为三组，分别服用4mg西洛多辛、8mg西洛多辛和安慰剂，每日一次，持续12周。结果 治疗后，4mg组有效率90.2%，8mg组87.8%，安慰剂组24.4%，4mg和8mg两组有效率与安慰剂组比较差异有统计学意义(P < 0.05)，4mg和8mg两组之间有效率比较差异无统计学意义（p>0.05）。治疗后，4mg和8mg两组患者疼痛不适评分、排尿症状评分、生活质量评分均显著降低，治疗前后差异均有统计学意义(P < 0.05)。治疗后，4mg和8mg两组患者前列腺液中IL-10、SIgA、VCAM-1水平均显著降低，治疗前后差异均有统计学意义(P < 0.05)，与安慰剂组比较具有统计学意义。在不良反应发生率上，4mg组9.80%，8mg组17.0%，安慰剂组29.3%，三组差异有统计学意义(P < 0.05)，结论 西洛多辛4mg或8mg治疗慢性前列腺炎都有很好的疗效，都能显著改善生活质量，降低炎症因子，但西洛多辛4mg的不良反应发生率低，可能有更好的安全性。

Abstract

Objective To evaluate the efficacy and safety of cilodoxine (4mg and 8mg) versus placebo inchronic prostatitis.
Methods: A total of 123 patients, aged 18 or above, who had not been treated before, were divided into three groups and given 4 mg, 8 mg cilodoxineand placebo once a day for 12 weeks
Results: After treatment, the effective rate is 90.2% in the 4mg group, 87.8% in the 8mg group and 24.4% in the placebo group. There are statistically significant differences in effective rates between 4mg and 8mg groups compared with placebo (P<0.05). There is no significant difference in effective rates between 4mg and 8mg groups (P>0.05). After treatment, pain and discomfort scores, urination symptom scores and quality of life scoresin 4mg and 8mg groups are significantly decreased, with statistical significance before and after treatment (P<0.05). After treatment, IL-10,SIgA and VCAM-1levels in prostatic fluid in 4mg and 8mg groups are significantly decreased, with statistical significance before and after treatment compared with placebo(P<0.05). The rate of side effects is 9.80% in the 4mg group, 17.0% in the 8mg group and 29.3% in the placebo group. Thereare statistically significant differences among the three groups(p<0.05).
Conclusion  s: Taking 4mg or 8 mg cilodoxine once a day in the treatment of chronic prostatitis have good efficacy, can significantly improve the quality of life, reduce inflammatory factors, but taking 4 mg has less side effects, it might be more secure.