Effect of basic insulin combined with metformin hydrochloride tablets in the treatmentof type 2 diabetes mellitus in community on blood glucose index and incidence of adverse reactions
基础胰岛素联合盐酸二甲双胍片治疗社区2型糖尿病对血糖指标及不良反应发生率的效果

摘要

目的 探究基础胰岛素联合盐酸二甲双胍片治疗社区2型糖尿病的临床效果。方法 研究时间设定于2020.01-2022.01，在此期间选择本社区卫生服务中心2型糖尿病患者资料作为研究主体，共计80名。按照随机分组法平均分出两组，每组40名建立不同治疗方案。常规组予以基础胰岛素治疗，实验组予以基础胰岛素联合盐酸二甲双胍片治疗。对比两组治疗前后血糖指标、不良反应发生率。结果 治疗前，两组对比血糖指标未见差异性，P＞0.05。治疗后，相较常规组，实验组血糖指标更低，P＜0.05。相较常规组，实验组不良反应发生率更低，P＜0.05。结论 社区2型糖尿病的治疗中选择盐酸二甲双胍片、基础胰岛素联合治疗方案更有利于血糖控制，减轻不良反应，获得良好治疗效果，建议推广。

Abstract

Objective To explore the clinical effect of basic insulin combined with metformin hydrochloride tablets in the treatment of type 2 diabetes mellitus in community.
Methods the study period was set from January 2020 to January 2022. During this period, 80 patients with type 2 diabetes in the community health service center were selected as the subjects of the study. According to the random grouping method, they were divided into two groups with 40 patients in each group to establish different treatment schemes. The routine group was treated with basic insulin, and the experimental group was treated with basic insulin combined with metformin hydrochloride tablets. The blood glucose indexes and the incidence of adverse reactions were compared between the two groups before and after treatment.
Results before treatment, there was no difference in blood glucose between the two groups (P > 0.05). After treatment, compared with the routine group, the blood glucose index of the experimental group was lower (P < 0.05). Compared with the routine group, the incidence of adverse reactions in the experimental group was lower (P < 0.05).
Conclusion   the combination of metformin hydrochloride tablets and basic insulin in the treatment of type 2 diabetes mellitus in the community is more conducive to blood glucose control, reduce adverse reactions, and achieve good treatment results. It is recommended to promote it.