Effect of metformin combined with ethanestradiol cyproterone tablets in the treatmentof polycystic ovary syndrome
二甲双胍联合炔雌醇环丙孕酮片治疗多囊卵巢综合征的疗效

摘要

目的 分析二甲双胍和炔雌醇环丙孕酮片联合用于多囊卵巢综合征的价值。方法 对2015年1月-2019年1月本科接诊多囊卵巢综合征病人（n=80）进行随机分组，试验和对照组各40人，前者用二甲双胍和炔雌醇环丙孕酮片，后者用炔雌醇环丙孕酮片。对比促卵泡激素等指标。结果 关于不良反应，试验组的数据是7.5%，和对照组的25.0%相比更低（P＜0.05）。关于促卵泡激素和黄体生成素，疗程结束之时：试验组的数据分别是（16.25±3.14）IU/L、（67.92±3.57）IU/L，和对照组的（30.64±4.19）IU/L、（80.65±4.72）IU/L相比更低（P＜0.05）。关于总有效率，试验组的数据是95.0%，和对照组的77.5%相比更高（P＜0.05）。结论 多囊卵巢综合征联用二甲双胍和炔雌醇环丙孕酮片，不良反应更少，激素水平改善更加明显，疗效也更好。

Abstract

Objective To analyze the value of metformin and eynestradiol cyproterone tablets combined for polycystic ovary syndrome.
Methods Patients with polycystic ovary syndrome (PCOS) admitted to our college from January 2015 to January 2019 (n=80) were randomly divided into two groups: the former was treated with metformin and eynestradiol cyproterone tablets, and the latter was treated with eynestradiol cyproterone tablets. Compare follicle stimulating hormone and other indicators.
Results The rate of adverse reactions in the experimental group was 7.5%, lower than that in the control group (25.0%) (P < 0.05). As for follicle-stimulating hormone (FSH) and luteinizing hormone (LH), at the end of the treatment course, the data of the experimental group were (16.25±3.14) IU/L and (67.92±3.57) IU/L, respectively, which were lower than those of the control group (30.64±4.19) IU/L and (80.65±4.72) IU/L (P < 0.05). As for the total effective rate, the data of the experimental group was 95.0%, which was higher than that of the control group (77.5%, P < 0.05).
Conclusion   Polycystic ovary syndrome combined with metformin and eynestradiol cyproterone tablets, less adverse reactions, more obvious hormone level improvement, better efficacy.