Clinical observation of bronchoalveolar lavage combined with roxithromycinin the treatment of bronchiectasis complicated with pulmonary infection
肺泡灌洗联合罗红霉素治疗支气管扩张并发肺部感染的临床疗效观察

摘要

目的 观察肺泡灌洗联合罗红霉素口服治疗支气管扩张并发肺部感染的临床疗效。方法 选取我院2020年10月-2021年10月收治的支气管扩张合并肺部感染患者共40例，随机分为对照组和观察组，各20例。对照组患者采用服用罗红霉素抗菌治疗。观察组在常规治疗的基础上行肺泡灌洗联合罗红霉素口服治疗；治疗1个月以及3个月后分别观察2组患者的支气管扩张症患者的临床总有效率、临床症状消失时长、PaCO₂及PaO₂指标数据。结果 经过三个月的治疗后，观察组的临床总有效率为95%，对照组的临床总有效率为85%；观察组咳嗽咳痰消失时间、退热时间和肺部炎性病灶消失时间明显均短于对照组；治疗后两组PaCO₂均下降，PaO₂均升高，但治疗组变化强度更大；两组治疗后的WBC、N%、hs-CRP、PCT均低于治疗前，观察组治疗后的WBC、N%、hs-CRP、PCT均低于治疗前和对照组。结论 采取罗红霉素口服联合肺泡灌洗有较好的治疗率，症状消失时间明显缩短，血气指标较观察组变化更大，安全性较高，适宜推广。

Abstract

Objective To observe the clinical effect of bronchoalveolar lavage combined with oral roxithromycin in the treatment of bronchiectasis complicated with pulmonary infection.
Methods A total of 40 patients with bronchiectasis complicated with pulmonary infection who were admitted to our hospital from October 2020 to October 2021 were selected and randomly divided into the control group and the observation group, 20 cases in each. The patients in the control group were treated with roxithromycin antibiotics. The observation group was given bronchoalveolar lavage combined with oral roxithromycin treatment on the basis of conventional treatment; after 1 month and 3 months of treatment, the clinical total effective rate, duration of clinical symptoms disappearance, PaCO2 in patients with bronchiectasis in the two groups were observed respectively. and PaO2 indicator data.
Results After three months of treatment, the total clinical effective rate of the observation group was 95%, and that of the control group was 85%; The time was significantly shorter than that in the control group; after treatment, PaCO2 decreased and PaO2 increased in both groups, but the intensity of changes in the treatment group was greater; WBC, N%, hs-CRP, and PCT in the two groups after treatment were lower than those before treatment, The WBC, N%, hs-CRP and PCT of the observation group after treatment were lower than those before treatment and the control group.
Conclusion   Taking roxithromycin orally combined with bronchoalveolar lavage has a good therapeutic rate, the symptom disappearance time is significantly shortened, and the blood gas indexes change more than the observation group, with high safety and suitable for promotion.