Comparison of amiodarone alone and combined with metoprolol in the treatment of coronary heart disease complicated with tachyarrhythmia
胺碘酮单用与联合美托洛尔治疗冠心病合并快速心律失常的疗效对比

摘要

目的 探讨在治疗冠心病并发快速心律失常患者时，单用胺碘酮及联用美托洛尔施治的疗效对比。方法 试验所选择对象是2020.04-2022.02此阶段内，在我院治疗的冠心病并发快速心律失常病患共计72例，根据随机数字表法均分作两组，治疗中对照组单用胺碘酮施治，观察组联用胺碘酮及美托洛尔施治，统计施治后两组血压、心率、总疗效及不良反应指标差异。结果 经对组间心率与血压指标进行比对，观察组收缩压、舒张压及心率指标水平比对照组低，P＜0.05；经对组间总疗效进行比对，观察组比对照组高，P＜0.05；经对比组间不良反应，观察组与对照组无显著性差异，P＞0.05。结论 治疗期间联用胺碘酮及美托洛尔治疗，可对患者心率进行调节，改善血压水平的同时，还可进一步提升临床疗效，且不易增加患者发生不良反应风险，适宜基层医院借鉴应用。

Abstract

Objective: To compare the efficacy of amiodarone alone and metoprolol in the treatment of patients with coronary heart disease complicated with tachyarrhythmia.
Methods: a total of 72 patients with coronary heart disease complicated with tachyarrhythmia treated in our hospital from April 2020 to February 2022 were randomly divided into two groups. During the treatment, the control group was treated with amiodarone alone, and the observation group was treated with amiodarone and metoprolol. The differences of blood pressure, heart rate, total curative effect and adverse reaction indexes between the two groups were counted.
Results: the levels of systolic blood pressure, diastolic blood pressure and heart rate in the observation group were lower than those in the control group (P < 0.05); The total curative effect of the observation group was higher than that of the control group (P < 0.05); There was no significant difference in adverse reactions between the observation group and the control group (P > 0.05).
Conclusion  : the combination of amiodarone and metoprolol during treatment can not only adjust the patient's heart rate and improve the blood pressure level, but also further improve the clinical efficacy, and it is not easy to increase the risk of adverse reactions. It is suitable for reference and application in grass-roots hospitals.