Therapeutic targets and Strategies of AMPK / NLRP3 inflammatory body axis in recurrent abortion
AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略

摘要

目的 分析AMPK/NLRP3炎性小体轴在复发性流产的治疗靶点及策略。方法 将2021-03至2022-02在我院诊治的43例复发性流产患者，列为研究组；另选择同时间内来我院治疗的43例单次流产后正常妊娠者，纳入对照组。两组均接受AMPK/NLRP3炎性小体轴、白细胞介素-1β（IL-1β）、白细胞介素-18（IL-18）、Th17/Treg、Th1/Th2检测，对比两组的检测结果。结果 研究组体内的AMPK/NLRP3炎性小体轴表达率显著高于对照组（P＜0.05）。在IL-1β、IL-18、Th17/Treg及Th1/Th2细胞上，研究组高于对照组（P＜0.05）。结论 AMPK/NLRP3炎性小体轴在复发性流产患者体内的表达率极高，可作为复发性流产的治疗靶点。

Abstract

Objective: To analyze the therapeutic targets and Strategies of AMPK / NLRP3 inflammatory body axis in recurrent abortion.
Methods: 43 patients with recurrent abortion treated in our hospital from March 2021 to February 2022 were included in the study group; In addition, 43 cases of normal pregnancy after single Abortion Treated in our hospital at the same time were included in the control group. Both groups received AMPK / NLRP3 inflammatory body axis and interleukin-1 β (IL-1 β), Interleukin-18 (IL-18), Th17 / Treg and Th1 / Th2 were detected, and the test results of the two groups were compared.
Results: the expression rate of AMPK / NLRP3 inflammatory body axis in the study group was significantly higher than that in the control group (P < 0.05). In IL-1 β, IL-18, Th17 / Treg and Th1 / Th2 cells in the study group were higher than those in the control group (P < 0.05).
Conclusion  : the expression rate of AMPK / NLRP3 inflammatory body axis in patients with recurrent abortion is very high, which can be used as a therapeutic target for recurrent abortion.