International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (2) ; 10.12208/j.ijcr.20220078 .
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庆阳市中医医院脾胃肝胆科 甘肃庆阳
*通讯作者： 李宏哲,单位：庆阳市中医医院脾胃肝胆科 甘肃庆阳；
目的 探讨清胃止血汤联合消化内镜治疗上消化道出血的临床疗效观察研究。方法 采用前瞻性随机对照研究将90例符合上消化道出血标准的患者纳入研究，其中男性42例，女性48例,男女比例=7:8,年龄25-67岁,平均（45.40±12.34）岁；病程6-16d，平均病程（9.31±2.76)d。依研究方案分为治疗组治疗组（清胃止血汤+消化内镜止血）与对照组（消化内镜止血）各45例。记录两组患者治疗后出血相关指标、有效率及复发率进行评价与统计学分析，比较两组的疗效差异。结果 两组患者治疗前后住院时间，出血量、平均止血时间等相关指标比较，以及两组患者治疗前后血小板、血红蛋白、尿素氮等指标的比较均存在统计学差异（均P<0.05）。两组患者治疗后有效率以及复发率的比较差异存在统计学意义（P<0.05）结论 清胃止血汤联合消化内镜治疗上消化到出血疗效确切、可操作性强，临床可推广使用。
Objective: To investigate the clinical efficacy of QingweiZhixue Decoction combined with digestive endoscopy in the treatment of upper gastrointestinal bleeding. Methods: A prospective randomized controlled study was used to include 90 patients who met the criteria for upper gastrointestinal bleeding, including 42 males and 48 females, male to female ratio = 7:8, age 25-67 years, mean (45.40±12.34) years old; the course of disease was 6-16 days, and the average course of disease was (9.31±2.76) days. According to the research plan, they were divided into a treatment group, a treatment group (QingweiZhixue Decoction + digestive endoscopy to stop bleeding) and a control group (digestive endoscopy to stop bleeding), 45 cases in each. The bleeding-related indexes, effective rate and recurrence rate of the two groups of patients after treatment were recorded for evaluation and statistical analysis, and the difference in curative effect between the two groups was compared. Results: There were significant differences in the hospitalization time, bleeding volume, average hemostasis time and other related indicators before and after treatment between the two groups, as well as the comparison of platelets, hemoglobin, urea nitrogen and other indicators before and after treatment between the two groups (all P<0.05). There were statistically significant differences in the effective rate and recurrence rate between the two groups after treatment (P<0.05). Conclusion : QingweiZhixue Decoction combined with digestive endoscopy has definite curative effect and strong operability in the treatment of upper digestion to bleeding, and can be widely used in clinical practice.
[1] 冯娜.观察上消化道出血采取消化内镜下金属钛夹止血的效果[J].中国现代药物应用,2021,15(19):86-88.
[2] 聂莹莹.消化内镜治疗上消化道出血的临床效果[J].上海医药,2021,42(17):43-45+48.
[3] 郑娜.消化内镜治疗上消化道出血的临床观察[J].中国医疗器械信息,2021,27(14):138-139.
[4] 李颖.研究消化内镜治疗上消化道出血后再出血的价值[J].中国医疗器械信息,2021,27(14):140-141.
[5] 祝灵敏.三黄泻心汤联合消化内镜治疗上消化道出血临床观察[J].光明中医,2019,34(07):986-987+995.
[6] 周庭源.康复新液联合消化内镜治疗急性上消化道出血[J].中国继续医学教育,2020,12(14):174-176.
[7] 李万勇.消化内镜在上消化道出血临床治疗中的应用效果[J].中国医药指南,2021,19(14):40-41.
[8] 张俊伟.消化内镜止血治疗对非静脉曲张性上消化道出血患者再出血及炎性反应的影响[J].临床医学工程,2021,28(05):591-592.
[9] 李万勇.消化内镜在上消化道出血临床治疗中的应用效果[J].中国医药指南,2021,19(14):40-41.
[10] 梁平,王亚培,海彬.情绪ABC理论下的家庭固定照顾者回授法干预对肝硬化合并上消化道出血患者内镜治疗术中心血管应激反应的影响[J].临床研究,2021, 29(06): 162-163.
[11] Deschamps J P, Allemand H, Gauffeny B, Evaluation Diagnostique et économique del'endoscopiedigestive haute enpremière intent dansl'explorationoeso- gastro- duodénale: Resultatsd'uneétude prospective, endehors des hémorragies digestives. A propos de 184 malades [Diagnostic and economical evaluation of upper digestive endoscopy as the initial investigation of lesions of the upper gastrointestinal tract. A prospective study in 184 unselected not bleeding patients (author's transl)]. Gastroenterol Clin Biol. 1982 Mar;6(3):229-34.
[12] Tacheci I, Devière J, Kopacova M. The importance of upper gastrointestinal lesions detected with capsule endoscopy in patients with obscure digestive bleeding. ActaGastroenterol Belg. 2011 Sep;74(3):395-9.
[13] 何帅,王妍.香砂六君子汤加味联合消化内镜治疗非静脉曲张性上消化道出血及对胃肠功能紊乱的影响[J].中国中西医结合消化杂志 2020，28（03）：219-222
[14] 臧丽丽,赵君.三黄泻心汤联合消化内镜治疗上消化道出血的临床研究[J].光明中医,2018,33(24):3714-3716.