The effect of high-flow heating and humidifying oxygen inhalation therapy on chronic obstructive pulmonary disease
高流量加温湿化吸氧治疗对慢性阻塞性肺疾病的治疗效果影响

摘要

目的 在本研究中针对慢性阻塞性肺病合璧的患者采用高流量加温湿化吸氧治疗，分析该方法的治疗效果。方法 挑选 COPD患者合并呼吸衰竭的患者共计200例，将其随机分为两组，每组100例，两组患者均采用常规抗感染、化痰、抑制气道炎症、纠正电解质紊乱等相关治疗，而观察组基于常规治疗的前提下采用高流量加温湿化吸氧治疗仪，对照组的患者基于常规治疗前提下采用持续低流量鼻导管氧气吸入的方式，分别比较两组患者在治疗前后的临床症状，心率，pH值，呼吸频率以及不良反应。结果 两组患者经过治疗之后心率、呼吸频率、PaCO2相比治疗之前有显著降低，而PaO2，SaO2相比治疗前有显著上升，在治疗前后对照组的ph无明显改善，而观察组pH在治疗前后有显著改善。观察组患者治疗之后呼吸频率降低且高于对照组，对照组PaCO2的降低程度要高，两组患者治疗之后pH值，心率，PaO2，SaO2无明显差异。在治疗之后，观察组痰液稀释、咳嗽患者有24例，对照组经过治疗之后痰液稀释，易咳出有13例，相比对照组，观察组明显要高，对照组中鼻部干燥不适的患者有9例，由于二氧化碳分压较高，需要通过无创通气的患者有4例，而观察组中感到鼻腔气流量较大的有13例，由于二氧化碳分压较高需要采取无创通气的患者有2例。结论 针对 COPD合并呼吸衰竭的患者采用高流量加温湿化吸氧治疗的方式其具有良好治疗效果，能够从一定程度上缓解患者呼吸频率，改善稀释痰液症状，在治疗时需要针对患者严密监测气血和其他临床症状，必要时采取机械通气的方式。

Abstract

Objective In this study, patients with chronic obstructive pulmonary disease were treated with high-flow heating and humidified oxygen inhalation therapy, and the therapeutic effect of this method was analyzed.
Methods A total of 200 patients with COPD combined with respiratory failure were selected and randomly divided into two groups with 100 cases in each group. Both groups were treated with conventional anti-infection, phlegm reduction, inhibition of airway inflammation, correction of electrolyte imbalance and other related treatments. The observation group was treated with a high-flow heating and humidified oxygen inhalation device under the premise of conventional treatment, and the patients in the control group were treated with continuous low-flow nasal cannula oxygen inhalation under the premise of conventional treatment. Clinical symptoms, heart rate, pH, respiratory rate, and adverse effects.
Results After treatment, the heart rate, respiratory rate and PaCO2 of the two groups of patients were significantly decreased compared with those before treatment, while PaO2 and SaO2 were significantly increased compared with those before treatment. The pH of the control group did not improve significantly before and after treatment, while the pH of the observation group increased significantly after treatment. Significant improvement before and after. After treatment, the respiratory rate of patients in the observation group decreased and was higher than that in the control group. The decrease degree of PaCO2 in the control group was higher. There was no significant difference in pH, heart rate, PaO2 and SaO2 between the two groups after treatment. After treatment, there were 24 cases of sputum dilution and cough in the observation group, and 13 cases in the control group with sputum dilution and easy coughing after treatment. Compared with the control group, the observation group was significantly higher, and the nose in the control group was dry and uncomfortable There are 9 patients who need non-invasive ventilation due to the high partial pressure of carbon dioxide, while 13 patients in the observation group feel that the nasal air flow is larger. There are 2 cases.
Conclusion   For COPD patients with respiratory failure, the high-flow heating and humidifying oxygen inhalation therapy has a good therapeutic effect. It can relieve the patient's breathing frequency and improve the symptoms of sputum dilution to a certain extent. Close monitoring of the patient is required during treatment. Qi, blood and other clinical symptoms, take mechanical ventilation if necessary.