International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (2) ; 10.12208/j.ijcr.20220054 .
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重庆医科大学附属儿童医院 重庆
*通讯作者： 范林,单位：重庆医科大学附属儿童医院 重庆；
门冬酰胺酶（Asp）是急性淋巴细胞性白血病（ALL）联合化疗中的关键药物，自临床应用以来，儿童急淋的总体生存率（OS）及长期无事件生存率(EFS)都有了很大程度的提高。然而其在发挥治疗作用的同时还会产生多种不良反应，如超敏反应、胰腺炎、血栓等，导致部分患儿Asp的截断，甚至死亡。
Asparaginase (Asp) is a key drug in the combined chemotherapy of acute lymphoblastic leukemia (ALL). Since its clinical application, the overall survival rate (OS) and long-term event free survival rate (EFS) of children with acute lymphoblastic leukemia have been greatly improved. However, while it plays a therapeutic role, it will also produce a variety of toxicity, such as hypersensitivity, pancreatitis, thrombosis, etc.,leading to the truncation of Asp in some children and even death.
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