Application value of serum C-peptide and glycosylated hemoglobin in the diagnosis of diabetes
血清C肽与糖化血红蛋白检测在糖尿病诊断中的应用价值

摘要

目的 探究并比较糖尿病诊断予以糖化血红蛋白与血清C肽检测的效能。方法 以我院2020年3月～2021年2月间接收的62例疑似糖尿病患者和58例健康体检人员为分析对象。采集所有人员的空腹静脉血液，进行血清C肽、糖化血红蛋白、空腹血糖与餐后2h血糖的检测。结果 糖尿病患者血清C肽水平（0.80±0.28）ug/L低于健康体检人员，糖化血红蛋白（9.08±1.52）%、空腹血糖（8.82±1.61）mmol/L及2h餐后血糖（12.62±2.22）mmol/L高于健康体检人员，差异P<0.05；62例疑似患者中共有58例明确糖尿病。血清C肽与糖化血红蛋白诊断单一使用的诊断结果相当（P>0.05），联合诊断的灵敏度（93.10%）、特异度（75.00%）、漏诊率（6.90%）以及误诊率（25.00%）均优于单一诊断（P<0.05）。结论 糖化血红蛋白与血清C肽的联合检测，更利于降低糖尿病诊断的漏误诊风险，值得宣传推广。

Abstract

Objective To explore and compare the efficacy of glycosylated hemoglobin and serum C-peptide detection in the diagnosis of diabetes.
Methods: A total of 62 suspected diabetic patients and 58 healthy people who were admitted to our hospital from March 2020 to February 2021 were selected as the analysis objects. Fasting venous blood was collected from all personnel, and serum C-peptide, glycosylated hemoglobin, fasting blood glucose and 2h postprandial blood glucose were detected.
Results: The serum C-peptide level of diabetic patients was (0.80±0.28) ug/L lower than that of healthy people, the glycated hemoglobin (9.08±1.52)%, fasting blood glucose (8.82±1.61) mmol/L and 2h postprandial blood glucose (12.62±2.22) ) mmol/L was higher than that of healthy people, the difference was P<0.05; A total of 58 of the 62 suspected patients were diagnosed with diabetes. The diagnostic results of serum C-peptide and glycosylated hemoglobin were comparable (P>0.05), and the combined diagnostic sensitivity (93.10%), specificity (75.00%), missed diagnosis rate (6.90%) and misdiagnosis rate (25.00%) were all excellent in a single diagnosis (P<0.05).
Conclusion  : The combined detection of glycosylated hemoglobin and serum C-peptide is more conducive to reducing the risk of misdiagnosis in the diagnosis of diabetes, and it is worthy of promotion.