Novel coronavirus pneumonia cured patients vaccinated COVID-19 Different doses of vaccine Antibody level analysis
新冠肺炎治愈患者接种新冠病毒疫苗不同剂次抗体水平分析

摘要

目的 研究新冠肺炎治愈患者接种新冠病毒灭活疫苗不同剂次的免疫效果。方法 将2020年赤壁市按现住址统计在中国疾病预防控制传染病报告信息管理系统报告的新冠肺炎治愈患者，自愿接受关爱康复项目，并签订知情同意书的84人纳入研究对象。采取询问新冠肺炎疫苗接种情况和对其进行新冠病毒抗体IgM及IgG检测，将检测出的1剂和2剂IgG抗体水平平均值进行T检验。结果 58人接种了1剂新冠病毒疫苗的新冠病毒IgG抗体水平在1.71～8.61范围，均数为6.56±1.68；22人接种的2剂新冠病毒疫苗，新冠病毒IgG抗体水平在0.29～8.56范围，均数为5.71±2.35，经T检验，t=0.72 P＞0.05，两者IgG水平无统计差异。结论 1、新冠肺炎治愈患者接种新冠病毒灭活疫苗只需要接种1剂，没必要接种2剂。2、部分没有接种新冠病毒疫苗的治愈患者，IgG抗体水平保持时间可达1年7个月之久。

Abstract

Objective China's novel coronavirus pneumonia was treated novel coronavirus pneumonia patients with different doses of COVID-19 inactivated vaccine.
Methods: in 2020, Chibi City, according to the current address, was collected from the new crown pneumonia patients reported by the China Disease Control and prevention reporting information management system, and the 84 people who voluntarily accepted the care rehabilitation project and signed informed consent were included in the study. A novel coronavirus pneumonia vaccine was inoculated and the IgM and IgG levels of COVID-19 antibodies were tested. The average level of 1 and 2 IgG antibodies tested was tested by T.
Results: the IgG antibody level of 58 people inoculated with 1 doses of COVID-19 vaccine ranged from 1.71 to 8.61, with a mean of 6.56±1.68. The 2 doses of COVID-19 vaccine inoculated with 22 persons and the level of COVID-19 IgG antibody ranged from 0.29 to 8.56, the mean value was 5.71 ±2.35. After T test, t=0.72 P > 0.05, there was no statistical difference in IgG level between the two groups.
Conclusion  : 1. Novel coronavirus pneumonia patients who received COVID-19 inactivated vaccine only need 1 doses of inoculation, and no need to inoculate 2 doses. 2. Some patients who did not receive COVID-19 vaccine were able to maintain the level of IgG antibody for 1 years and 7 months.