International Journal of Clinical Research
International Journal of Clinical Research. 2022; 6: (1) ; 10.12208/j.ijcr.20220012 .
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滨州医学院烟台附属医院呼吸与危重症医学科 山东烟台
滨州医学院烟台附属医院心血管内科 山东烟台
滨州医学院第二临床医学院 山东滨州
滨州医学院第一临床医学院 山东滨州
*通讯作者： 杨坚,单位：滨州医学院烟台附属医院呼吸与危重症医学科 山东烟台；
华法林是临床上最常用于预防和治疗血栓栓塞性疾病的一线抗凝药物，最常见的不良反应为出血。儿童心脏瓣膜病术后的气管支气管钙化和长期使用华法林有关，成人心脏瓣膜置换术后、肺栓塞、深静脉血栓和心房颤动等疾病长期使用华法林也可诱导气管支气管钙化。这是华法林一种比较罕见的不良反应，且国内的相关报道罕见。现将滨州医学院烟台附属医院收治的长期使用华法林诱导的气管支气管弥漫钙化病例1例报道如下。
Warfarin is the most used first-line anticoagulant for the prevention and treatment of thromboembolic diseases, whose most common adverse reaction is bleeding.Long-term use of warfarin is associated with tracheobronchial calcification after valvular heart disease in children, while long-term use of warfarin in adults can also induce tracheobronchial calcification after heart valve replacement, pulmonary embolism, deep vein thrombosis, and atrial fibrillation.This is a relatively rare adverse reaction of warfarin, and the relevant reports in China are rare.A case of long-term warfarin induced diffuse tracheobronchial calcification admitted to Yantai Affiliated Hospital of Binzhou Medical College is reported as follows.
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