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国际临床研究杂志

International Journal of Clinical Research

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International Journal of Clinical Research. 2021; 5: (4) ; 10.12208/j.ijcr.20210051 .

Mechanism of brain injury and long-term neurodevelopmental impairmentin neonatal purulent meningitis
新生儿化脓性脑膜炎脑损伤机制及长期神经发育损害

作者: 尤海容 , 邓春 *

重庆医科大学附属儿童医院 重庆

*通讯作者: 邓春,单位:重庆医科大学附属儿童医院 重庆;

收录截图(CNKI-Scholar)

引用本文: 尤海容 , 邓春 新生儿化脓性脑膜炎脑损伤机制及长期神经发育损害[J]. 国际临床研究杂志, 2021; 5: (4) : 93-98.
Published: 2021/12/10 11:26:31

摘要

血脑屏障的破坏、小胶质细胞激活、炎症损伤会对早期大脑发育产生不利影响,导致婴儿的长期神经损伤。在新生儿中预防感染、早期管理、密切随访和早期干预的策略仍然是改善结果的基础。

关键词: 新生儿;化脓性脑膜炎;脑损伤;小胶质细胞;炎症;神经发育损害

Abstract

The destruction of blood-brain barrier, activation of microglia and inflammatory injury will have adverse effects on early brain development and lead to long-term nerve injury in infants. Strategies for infection prevention, early management, close follow-up and early intervention in newborns remain the basis for improving outcomes.

Key words: Newborn; Purulent Meningitis; Brain Damage; Microglia; Inflammation; Neurodevelopmental Damage

参考文献 References

[1] 胡亚美. 诸福棠实用儿科学[J]. 人民卫生出版社, 2002.

[2] Webbe J,Duffy J,Afonso E,et al. Core Outcomes in Neonatology: Development of a Core Outcome Set for Neonatal Research[J]. Archives of Disease in Childhood - Fetal and Neonatal Edition, 2020 Jul;105(4):425-431.

[3] Sewell E,Roberts J,Mukhopadhyay S. Association of Infection in Neonates and Long-term Neurodevelopmental Outcome[J]. Clinics in Perinatology, 2021, 48(2):251-261.

[4] Ku LC, Boggess KA, Cohen-wolkowiez M. Bacterial Meningitis in Infants[J]. Clinics in Perinatology, 2015, 42(1): 29-45.

[5] Okike IO, Ladhani SN, Johnson AP, et al. Clinical Characteristics and Risk Factors for Poor Outcome in Infants Less Than 90 Days of Age with Bacterial Meningitis in the United Kingdom and Ireland[J]. Pediatric Infectious Disease Journal,2018 Sep; 37(9): 837-843.

[6] Schuchat A, Robinson K, Ph M, et al. Bacterial Meningitis in the United States, 1998-2007.[J]. New England Journal of Medicine, 1997, 337(14): 970-976.

[7] Kadambari S, Trotter CL, Heath PT, et al. Group B Streptococcal Disease in England (1998 - 2017): a Population Based Observational Study[J]. Clinical Infectious Diseases, 2021 Jun 1; 72(11):e791-e798.

[8] Doctor BA, Newman N, Minich NM, et al. Clinical Outcomes of Neonatal Meningitis in Very-low-birth- weight Infants[J]. Clinical Pediatrics, 2001, 40(9): 473-480.

[9] Maya KL, Russell NJ, Seale AC, et al. Neurodevelo- pmental Impairment in Children After Group B Streptococcal Disease Worldwide: Systematic Review and Meta- analyses[J]. Clinical Infectious Diseases an Official Publication of the Infectious Diseases Society of America, 2017 Nov 6;65(suppl_2):S190-S199.

[10] Stevens, J. P, Eames, et al. Long Term Outcome of Neonatal Meningitis.[J]. Archives of Disease in Childhood Fetal & Neonatal Edition,2003 May;88(3):F179-84.

[11] Libster R, Edwards KM, Levent F, et al. Long-term Outcomes of Group B Streptococcal Meningitis[J]. Pediatrics, 2012 Jul;130(1):e8-15.

[12] Louvois J, Halket S, Harvey D. Neonatal Meningitis in England and Wales: Sequelae at 5 Years of Age[J]. European Journal of Pediatrics, 2005, 164(12): 730-734.

[13] Louvois JD,Blackbourn J,Hurley R,et al. Infantile Meningitis in England and Wales: a Two Year Study.[J]. Archives of Disease in Childhood, 1991, 66(5): 603-607.

[14] Klinger G, Chin CN, Beyene J, et al. Predicting the Outcome of Neonatal Bacterial Meningitis[J]. Pediatrics, 2000 Sep; 106(3): 477-82.

[15] Harvey D, Holt DE, Bedford H. Bacterial Meningitis in the Newborn: a Prospective Study of Mortality and Morbidity[J]. Seminars in Perinatology, 1999, 23(3): 218-225.

[16] 赵智. 新生儿化脓性脑膜炎的多中心回顾性临床流行病学研究[D].: 重庆医科大学, 2016.

[17] Okike IO, Johnson AP, Henderson KL, et al. Incidence, Etiology, and Outcome of Bacterial Meningitis in Infants Aged <90 Days in the United Kingdom and Republic of Ireland: Prospective, Enhanced, National Population- based Surveillance.[J]. Clinical Infectious Diseases,2014 Nov 15; 59(10):e150-7.

[18] Bowes, Jennifer, Roberts, et al. The Epidemiology, Management, and Outcomes of Bacterial Meningitis in Infants[J]. Pediatrics: Official Publication of the American Academy of Pediatrics,2017 Jul;140(1):e20170476.

[19] Sorge NV, Doran KS. Defense at the Border: the Blood– brain Barrier Versus Bacterial Foreigners[J]. Future Microbiology, 2012, 7(3): 383-394.

[20] Rui PM, Sousa F, Almeida A, et al. Theranostic Biomaterials for the Regulation of the Blood-brain Barrier[J]. Micro and Nano Technologies, 2019, 303-319.

[21] Hawkins, B. T. The Blood-brain Barrier/neurovascular Unit in Health and Disease[J]. Pharmacological Reviews, 2005, 57(2): 173-185.

[22] Davoust N, Vuaillat C, Androdias G, et al. From Bone Marrow to Microglia: Barriers and Avenues[J]. Trends in Immunology, 2008, 29(5): 227-234.

[23] Konsman J, Drukarch B, Van?dam AM. (peri)vascular Production and Action of Pro-inflammatory Cytokines in Brain Pathology[J]. Clinical Science, 2007, 112(1): 1-25.

[24] Wolburg H, Wolburg-buchholz K, Engelhardt B. Diapedesis of Mononuclear Cells Across Cerebral Venules During Experimental Autoimmune Encephalomyelitis Leaves Tight Junctions Intact[J]. Acta Neuropathologica, 2005, 109(2): 181-190.

[25] Teng CH, Cai M, Shin S, et al. Escherichia Coli K1 Rs218 Interacts with Human Brain Microvascular Endothelial Cells Via Type 1 Fimbria Bacteria in the Fimbriated State[J]. Infection & Immunity, 2005, 73(5): 2923.

[26] Khan NA, Wang Y, Kim KJ, et al. Cytotoxic Necrotizing Factor-1 Contributes to Escherichia Coli K1 Invasion of the Central Nervous System[J]. Journal of Biological Chemistry, 2002, 277(18): 15607.

[27] Kim KJ, Chung JW, Kim KS. 67-kda Laminin Receptor Promotes Internalization of Cytotoxic Necrotizing Factor 1-expressing Escherichia Coli K1 Into Human Brain Microvascular Endothelial Cells[J]. Journal of Biological Chemistry, 2005, 280(2): 8-1360.

[28] Prasadarao NV, Blom AM, Villoutreix BO, et al. A Novel Interaction of Outer Membrane Protein a with C4b Binding Protein Mediates Serum Resistance of Escherichia Coli K1[J]. Journal of Immunology, 2002, 169(11): 6352.

[29] Zhou Y, Tao J, Yu H, et al. Hcp Family Proteins Secreted Via the Type Vi Secretion System Coordinately Regulate Escherichia Coli K1 Interaction with Human Brain Microvascular Endothelial Cells[J]. Infection & Immunity, 2012, 80(3): 1243.

[30] Mittal R, Prasadarao NV. Nitric Oxide/cgmp Signalling Induces Escherichia Coli K1 Receptor Expression and Modulates the Permeability in Human Brain Endothelial Cell Monolayers During Invasion[J]. Cellular Microbiology, 2010, 12(1): 67-83.

[31] Morven, S, Edwards, et al. Group B Streptococcal Infections in Elderly Adults.[J]. Clinical Infectious Diseases an Official Publication of the Infectious Diseases Society of America,2005 Sep 15;41(6):839-47.

[32] Rosa-fraile M, Dramsi S, Spellerberg B. Group B Streptococcal Haemolysin and Pigment, a Tale of Twins[J]. Fems Microbiology Reviews, 2014, 38(5): 932-946.

[33] Tazi A, Disson O, Bellais S, et al. The Surface Protein Hvga Mediates Group B Streptococcus Hypervirulence and Meningeal Tropism in Neonates[J]. Journal of Experimental Medicine, 2010, 207(11): 2313-2322.

[34] Kim, Sik K. Mechanisms of Microbial Traversal of the Blood-brain Barrier.[J]. Nature Reviews Microbiology, 2008, 6(8): 625-634.

[35] Seo HS, Mu R, Kim BJ, et al. Binding of Glycoprotein Srr1 of Streptococcus Agalactiae to Fibrinogen Promotes Attachment to Brain Endothelium and the Development of Meningitis[J]. Plos Pathogens, 2012, 8(10): 0.

[36] Barichello T, Lemos JC, Generoso JS, et al. Oxidative Stress, Cytokine/chemokine and Disruption of Blood- brain Barrier in Neonate Rats After Meningitis By Streptococcus Agalactiae.[J]. Neurochemical Research, 2011, 36(10): 30-1922.

[37] Billiards SS, Haynes RL, Folkerth RD, et al. Development of Microglia in the Cerebral White Matter of the Human Fetus and Infant.[J]. Journal of Comparative Neurology, 2010, 497(2): 199-208.

[38] Kannan S, Saadani-makki F, Balakrishnan B, et al. Magnitude of [c-11]pk11195 Binding Is Related to Severity of Motor Deficits in a Rabbit Model of Cerebral Palsy Induced By Intrauterine Endotoxin Exposure[J]. Developmental Neuroscience, 2011, 33(3): 231-240.

[39] Kelley MH, Wu WW, Lei J, et al. Functional Changes in Hippocampal Synaptic Signaling in Offspring Survivors of a Mouse Model of Intrauterine Inflammation[J]. Journal of Neuroinflammation, 2017, 14(1): 180.

[40] Hammond TR, Daisy R, Beth S. Microglia and the Brain: Complementary Partners in Development and Disease[J]. Annual Review of Cell and Developmental Biology, 2018, 34(1): 0-0.

[41] Wynn JL, Levy O. Role of Innate Host Defenses in Susceptibility to Early-onset Neonatal Sepsis[J]. Clinics in Perinatology, 2010, 37(2): 307-337.

[42] Wynn JL, Scumpia PO, Winfield RD, et al. Defective Innate Immunity Predisposes Murine Neonates to Poor Sepsis Outcome but Is Reversed By Tlr Agonists.[J]. Blood, 2008, 112(5): 1750.

[43] Vela JM, Molina-holgado E, Arévalo-martín A, et al. Interleukin-1 Regulates Proliferation and Differentiation of Oligodendrocyte Progenitor Cells.[J]. Molecular & Cellular Neuroscience, 2002, 20(3): 489-502.

[44] Folkerth RD, Keefe RJ, Haynes RL, et al. Interferon‐γ Expression in Periventricular Leukomalacia in the Human Brain[J]. Brain Pathology, 2004 Jul;14(3):265-74.

[45] Back SA, Ning LL, Mallinson RA, et al. Selective Vulnerability of Preterm White Matter to Oxidative Damage Defined By F2-isoprostanes.[J]. Annals of Neurology, 2010, 58(1): 108-120.

[46] Romain B, Stéphane B, Philippe B, et al. Escherichia Coli Meningitis Features in 325 Children From 2001 to 2013 in France[J]. Clinical Infectious Diseases an Official Publication of the Infectious Diseases Society of America, 2015, (5): 779.

[47] Stoll BJ, Hansen NI, Adams-chapman I, et al. Neurodevelopmental and Growth Impairment Among Extremely Low-birth-weight Infants with Neonatal Infection[J]. Jama the Journal of the American Medical Association, 2004, 292(19): 2357-2365.

[48] Tsoni K, Papadopoulou E, Michailidou E, et al. Campylobacter Jejuni Meningitis in a Neonate: a Rare Case Report[J]. Journal of Neonatal-perinatal Medicine, 2013, 6(2): 5-183.