International Journal of Clinical Research
International Journal of Clinical Research. 2021; 5: (4) ; 10.12208/j.ijcr.20210032 .
总浏览量: 1218
复旦大学附属妇产科医院 上海
*通讯作者： 鹿欣,单位：复旦大学附属妇产科医院 上海；
妊娠滋养细胞疾病（gestational trophoblastic disease, GTD）是一组以滋养细胞异常增殖为特征的疾病。由于GTD较为罕见，部分临床医生对其诊治经验不足。许多国家和地区成立了GTD诊疗中心。这些诊疗中心使GTD的诊治更加规范，也为相关研究的开展提供了丰富的资料。本文对全球GTD诊疗中心的分布及其疾病管理模式进行了汇总，并对我国成立GTD中心的必要性和可行性加以探讨。
Gestational trophoblastic diseases (GTD) are a group of diseases characterized by abnormal proliferation of trophoblast cells. Because of its rarity, some clinicians may have insufficient experience in the diagnosis and treatment. Thus, GTD centers were established in many countries worldwide, which have standardized the management of GTD and provided plenty data for research. This article summarized the global distribution as well as management strategies of GTD centers worldwide, and discussed the necessity and feasibility of establishing GTD centers in China.
[1] Ngan HYS, Seckl MJ, Berkowitz RS, et al. Update on the diagnosis and management of gestational trophoblastic disease [J]. International Journal of Gynecology and Obstetrics, 2018, 143(Supplement 2): 79-85.
[2] Altman AD, Bentley B, Murray S, et al. Maternal age-related rates of gestational trophoblastic disease [J]. Obstetrics and Gynecology, 2008, 112(2 Pt 1): 244-50.
[3] Eysbouts YK, Bulten J, Ottevanger PB, et al. Trends in incidence for gestational trophoblastic disease over the last 20 years in a population-based study [J]. Gynecologic oncology, 2016, 140(1): 70-5.
[4] Joneborg U, Folkvaljon Y. Temporal trends in incidence and outcome of hydatidiform mole: a retrospective cohort study [J]. Acta oncologica (Stockholm, Sweden), 2018, 57(8): 1094-9.
[5] Smith HO, Wiggins C, Verschraegen CF, et al. Changing trends in gestational trophoblastic disease [J]. The Journal of Reproductive Medicine, 2006, 51(10): 777-84.
[6] Duff GB. Gestational trophoblastic disease in New Zealand, 1980-1986 [J]. The Australian & New Zealand Journal of Obstetrics &Gynaecology, 1989, 29(2): 139-42.
[7] Talati NJ. The pattern of benign gestational trophoblastic disease in Karachi [J]. JPMA The Journal of the Pakistan Medical Association, 1998, 48(10): 296-300.
[8] Aghababaii S, Shobeiri F, Hosseinipanah SM. Hydatidiform mole: A statistical survey in west of Iran [J]. Journal of Postgraduate Medical Institute, 2016, 30(1): 80-3.
[9] Harma M, Harma M, Yurtseven S, et al. Gestational trophoblastic disease in Sanliurfa, southeast Anatolia, Turkey [J].European Journal of Gynaecological Oncology, 2005, 26(3): 306-8.
[10] Yuk JS, Baek JC. Incidence of gestational trophoblastic disease in South Korea: a longitudinal, population-based study [J]. PeerJ, 2019, 7(e6490.
[11] Matsui H, Iitsuka Y, Yamazawa K, et al. Changes in the incidence of molar pregnancies. A population-based study in Chiba Prefecture and Japan between 1974 and 2000 [J]. Human reproduction (Oxford, England), 2003, 18(1): 172-5.
[12] Lurain JR. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole [J]. American Journal of Obstetrics and Gynecology, 2010, 203(6): 531-9.
[13] 全国绒癌协作组. 全国23个省、市、自治区二百余万妇女葡萄胎发病率调查初步总结 [J]. 中华医学杂志, 1980, 60(11): 641-4.
[14] 石一复, 李娟清, 郑伟, et al. 360余万次妊娠中妊娠滋养细胞疾病发生情况调查 [J]. 中华妇产科杂志, 2005, 40(2): 76-8.
[15] Ireson J, Singh K, Gillett S, et al. Evolution of a specialist gestational trophoblastic disease service with a major nursing component: the Sheffield, United Kingdom, experience [J]. The Journal of Reproductive Medicine, 2014, 59(5-6): 195-8.
[16] Kohorn E. Regional centers for trophoblastic disease [J]. American Journal of Obstetrics and Gynecology, 2007, 196(2): 95-6.
[17] Brewer JI, Eckman TR, Dolkart RE, et al. Gestational trophoblastic disease. A comparative study of the results of therapy in patients with invasive mole and with choriocarcinoma [J]. American Journal of Obstetrics and Gynecology, 1971, 109(2): 335-40.
[18] Hando T, Ohno M, Kurose T. Recent aspects of gestational trophoblastic disease in Japan [J]. International Journal of Gynaecology and Obstetrics, 1998, 60 Suppl 1(S71-6.
[19] Dantas PR, Maestá I, Cortés-Charry R, et al. Influence of hydatidiform mole follow-up setting on postmolar gestational trophoblastic neoplasia outcomes: a cohort study [J]. The Journal of Reproductive Medicine, 2012, 57(7-8): 305-9.
[20] Kohorn EI. Worldwide survey of the results of treating gestational trophoblastic disease [J]. The Journal of Reproductive Medicine, 2014, 59(3-4): 145-53.
[21] 冯凤芝, 向阳, 贺豪杰, et al. 宫腔镜和腹腔镜在妊娠滋养细胞肿瘤鉴别诊断中的价值 [J]. 中华妇产科杂志, 2007, 42(7): 464-7.
[22] Hancock BW, Nazir K, Everard JE. Persistent gestational trophoblastic neoplasia after partial hydatidiform mole incidence and outcome [J]. The Journal of Reproductive Medicine, 2006, 51(10): 764-6.
[23] Fisher RA, Maher GJ. Genetics of gestational trophoblastic disease [J]. Best practice & research Clinical obstetrics & gynaecology, 2021, 74(29-41.
[24] Rozenholc A, Dodge J, Bréguet M, et al. Gestational Trophoblastic Disease: Opportunities for a National Registry Collaboration [J]. International journal of gynecological cancer : official journal of the International Gynecological Cancer Society, 2016, 26(6): 1182-5.
[25] Seckl MJ, Sebire NJ, Fisher RA, et al. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up [J]. Annals of oncology : official journal of the European Society for Medical Oncology, 2013, 24 Suppl 6(vi39-50.
[26] Golfier F, Raudrant D, Frappart L, et al. First epidemiological data from the French Trophoblastic Disease Reference Center [J]. American journal of obstetrics and gynecology, 2007, 196(2): 172.e1-5.
[27] Clark LH, Staley SA, Barber EL, et al. The effect of distance traveled on disease outcomes in gestational trophoblastic neoplasia [J]. American journal of obstetrics and gynecology, 2016, 215(2): 217.e1-5.
[28] Braga A, Burlá M, Freitas F, et al. Centralized Coordination of Decentralized Assistance for Patients with Gestational Trophoblastic Disease in Brazil: A Viable Strategy for Developing Countries [J]. The Journal of reproductive medicine, 2016, 61(5-6): 224-9.