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国际遗传前沿杂志

International Journal of Genetics Frontiers

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International Journal of Genetics Frontiers. 2020; 1: (1) 2; 10.12208/j.ijgf.20200002 .

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Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people
DNATyper X19试剂盒在中国北方汉族人的遗传多态性

作者： YU Zhengliang, CAI Huiju, MA Wenhua, MO Xiaoting, YAO Yiren, WANG Le, LIU Chao, ZHAO Xingchun, LI Wanshui *

公安部法医学研究所

广州法医所

*通讯作者： LI Wanshui,单位：公安部法医学研究所；

收录截图（CNKI-Scholar）

引用本文: YU Zhengliang, CAI Huiju, MA Wenhua, MO Xiaoting, YAO Yiren, WANG Le, LIU Chao, ZHAO Xingchun, LI Wanshui DNATyper X19试剂盒在中国北方汉族人的遗传多态性[J]. 国际遗传前沿杂志, 2020; 1: (1) : 5-11.

Published: 2020/6/17 11:26:23

摘要

目的评估DNATyper X19试剂盒在法医学应用中的价值。方法在这项研究中，我们对374名中国北方汉族个体的遗传多态性进行了调查。结果在374名华北汉族人群的18个X-STR基因座中共检测到140个等位基因，从228名男性中检测出228个单倍型，多样性为100％。在这项研究中，应用Bonferroni校正进行多次测试后（p = 0.05 / 18），没有标记脱离Hardy-Weinberg平衡，GATA31E08-DXS6797，DXS8377-DXS10079处于连锁不平衡（LD）（p = 0.05 / 153）。多态信息含量（PIC）为0.434-0.908，判别力（DP）为0.432-0.983。男性的综合分辨力为0.99999993，女性为0.999999992。双重病例（CMECduo）的合并平均排除机会为0.999993，三重病例（CMECtrio）为0.999999994。结论 DNATyper X19试剂盒对复杂的父系案件具有潜在价值。

关键词： 法医遗传学，X染色体，X-STR

Abstract

Objective To evaluate the value of DNATyper X19 kit in the forensic application.
Methods In this study, we carried out a survey of genetic polymorphism from 374 Northern Chinese Han individuals.
Results A total of 140 alleles were detected among the 18 X-STR loci from 374 Northern Chinese Han individuals, 228 haplotypes were detected from the 228 males, the diversity is 100%. No markers departed from Hardy-Weinberg equilibrium after applying Bonferroni’s correction for multiple testing (p=0.05/18), GATA31E08-DXS6797, DXS8377-DXS10079 were in linkage disequilibrium (LD) in this study (p=0.05/153). The polymorphism information content (PIC) was 0.434-0.908 and the discrimination power (DP) was 0.432-0.983. The combined discrimination power was 0.99999993 for male and 0.999999992 for female. The combined mean exclusion chance was 0.999993 in duo cases (CMECduo) and 0.999999994 in trio case (CMECtrio).
Conclusion s DNATyper X19 kit showed potential value for complicated paternity cases.

Key words： Forensic Genetics, X Chromosome, X-STR

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Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han peopleDNATyper X19试剂盒在中国北方汉族人的遗传多态性

摘要

Abstract

参考文献 References

Genetic polymorphism of DNATyper X19 kit in Northern Chinese Han people
DNATyper X19试剂盒在中国北方汉族人的遗传多态性