Objective To investigate the status of irrational drug use in gastroenterology. Methods A retrospective analysis of 150 cases of unreasonable drug use in our hospital from January 2018 to January 2019. Results Among the 150 patients selected in this study, there were 39, 22, 35, and 54 cases of drug antagonism, repeated use, unreasonable combination, and excessive drug use, accounting for 26.00%, 14.67%, and 23.00%, respectively. And 36.00%. Conclusion Irrational drug use is a common problem in the department of gastroenterology. Therefore, relevant personnel are required to pay more attention to it and reduce the phenomenon of irrational drug use through effective prevention measures.