[Abstract]Objective:To investigate the clinical effect of Amiodarone in ventricular arrhythmia patients with acute myocardial infarction. Method:108 ventricular arrhythmia patients with acute myocardial infarction were enrolled and randomly subdivided into 2 groups: the control group was given lidocaine and the experimental group was given Amiodarone. Observing index included left ventricular ejection fraction (LVEF), electrocardiogram(ECG) and side effects. Results:Total effective rate is higher in the experimental group (92.59%) than the control group(61.11%). In addition, Amiodarone showed greater effect in LVEF, the number of arrhythmia, QRS duration and PR. Conclusion s: In acute myocardial infarction, Amiodarone is effective and safe.