Clinical effect comparison of rifampicin and rifapentine in the treatment of elderly pulmonary tuberculosis
利福平与利福喷丁在老年肺结核治疗中的临床效果比较

摘要

目的 对比利福平与利福喷丁在老年肺结核治疗中的临床效果。方法 选取87例老年肺结核患者，随机分为对照组（43例，采用利福平治疗）与干预组（44例，采用利福喷丁治疗），进行为期6个月的治疗观察，通过比较两组患者治疗后的病灶吸收情况、痰菌转阴率及不良反应发生情况，评估两种药物的临床疗效。结果 干预组在病灶吸收率、痰菌转阴率方面优于对照组，且不良反应发生率更低，表明利福喷丁在老年肺结核治疗中展现出更优的临床效果。

Abstract

Objective To compare the clinical effect of rifampicin and rifapentine in the treatment of elderly pulmonary tuberculosis.
Methods 87 elderly patients with pulmonary tuberculosis were randomly divided into the control group (43 cases, treated with rifampicin) and the intervention group (44 cases, treated with rifapentine). The treatment was observed for 6 months. The clinical efficacy of the two drugs was evaluated by comparing the lesion absorption, sputum negative conversion rate and the incidence of adverse reactions between the two groups after treatment.
Results the focus absorption rate and sputum negative conversion rate of the intervention group were better than those of the control group, and the incidence of adverse reactions was lower, indicating that rifapentine showed a better clinical effect in the treatment of elderly pulmonary tuberculosis.