Geriatric Medicine and Chronic Disease Management
Geriatric Medicine and Chronic Disease Management. 2026; 1: (1) ; 10.12208/j.gmcdm.20260003 .
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1秋文大学成人护理系 日本
2名古屋大学医院社区联络和患者咨询中心 日本
3名古屋大学医学研究生院健康科学学院社区和家庭护理系 日本
4伊那诊所内科 日本
5名古屋大学医学研究生院社区医疗保健与老年医学系 日本
*通讯作者： Akemi Hirano,单位：秋文大学成人护理系 日本; ；
背景 照护者的估算肾小球滤过率（eGFR）通常低于非照护者。目前鲜有研究探讨影响痴呆症患者照护者肾素-血管紧张素系统（RAS）的因素，而照护者往往承受着照护带来的身心双重压力。目的 本研究旨在探讨影响痴呆症患者照护者RAS的健康因素。方法 本研究采用横断面研究设计，纳入痴呆症患者的老年照护者。测量每位照护者的肾素和醛固酮水平，并进行逻辑回归分析。结果 照护者的性别和体重指数（BMI）是影响痴呆症患者照护者RAS的因素。讨论 慢性压力可能导致照护者体内醛固酮和肾素水平升高。男性照护者的肾素水平显著高于女性照护者，提示男性在照护过程中交感神经活动可能比日本女性更为显著。导致肥胖的因素，例如因照护工作带来的身心疲惫而养成的不良生活习惯，也可能产生影响。结论 需要加大对男性照护者的支持力度，尤其是在照护工作和健康管理方面。此外，还必须确定其他导致照护者体重指数（BMI）升高的因素。
Background Caregivers tend to have a lower estimated glomerular filtration rate (eGFR) than non-caregivers. Few studies have identified factors that affect the renin-angiotensin system in caregivers of dementia patients, who are under combined physical and psychological stress from caregiving. Purpose The present study aimed to determine health factors that affect the renin-angiotensin system in caregivers of patients with dementia. Methods A cross-sectional study was conducted among elderly caregivers of patients with dementia. Levels of renin and aldosterone were measured in each caregiver. Logistic regression analysis was performed. Results Caregiver sex and BMI were identified as factors that influence the renin-angiotensin system in caregivers of dementia patients. Discussion Chronic stress may increase aldosterone and renin levels in caregivers. Male caregivers had significantly higher renin levels than female caregivers, suggesting that the sympathetic activity in men may increase more markedly during caregiving than that observed in women in Japan. Factors that promote obesity, such as detrimental lifestyle habits that develop from the physical and mental fatigue of caregiving, may also have an impact. Conclusion Increased support is needed for male caregivers, specifically for their caregiving efforts and health management. Other factors that increase caregiver BMI must also be identified.
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