Clinical analysis of Shenqi Dihuang Decoction plus conventional western medicine in the treatment of qi yin deficiency syndrome of stage Ⅲ diabetes nephropathy
参芪地黄汤加减联合西医常规疗法治疗Ⅲ期糖尿病肾病气阴两虚证临床分析

摘要

目的 探析参芪地黄汤加减与西医常规疗法联合治疗III期糖尿病肾病气阴两虚证的效果。方法 自2024年7月起，本院开始收集诊治III期糖尿病肾病气阴两虚证的病例资料，至2025年7月止共纳入76例，通过抽单双号法进行平均分组。一组38例采取西医常规疗法治疗设为参照组；一组38例采取参芪地黄汤加减联合西医常规疗法治疗设为实验组。对比两组血糖水平、肾功能、中医证候积分等情况。结果 实验组空腹血糖、餐后2h血糖以及糖化血红蛋白水平较参照组明显偏低（P<0.05）。实验组肾功能指标水平较参照组明显偏低（P<0.05）。实验组各项中医证候积分较参照组明显偏低（P<0.05）。结论 参芪地黄汤加减与西医常规疗法联合治疗III期糖尿病肾病气阴两虚证患者，可有效控制血糖水平，明显提升肾功能，改善中医证候效果更佳，应进一步推广。

Abstract

Objective To explore the effect of Shenqi Dihuang Decoction and conventional western medicine in the treatment of stage III diabetes nephropathy with deficiency of both qi and yin.
Methods From July 2024, our hospital began to collect the case data of the diagnosis and treatment of qi yin deficiency syndrome of stage III diabetes nephropathy. By July 2025, 76 cases were included, and were divided into average groups by the method of drawing single and double numbers. A group of 38 cases were treated with conventional Western medicine therapy and set as the reference group; A group of 38 cases were treated with modified Shenqi Dihuang Decoction combined with conventional Western medicine therapy as the experimental group. Compare the blood glucose levels, renal function, and traditional Chinese medicine syndrome scores between two groups.
Results The fasting blood glucose, 2-hour postprandial blood glucose, and glycated hemoglobin levels in the experimental group were significantly lower than those in the reference group (P<0.05). The levels of renal function indicators in the experimental group were significantly lower than those in the reference group(P<0.05). The scores of various TCM syndromes in the experimental group were significantly lower than those in the reference group (P<0.05).
Conclusion   The combination of Shenqi Dihuang Decoction and conventional western medicine therapy can effectively control blood sugar level, significantly improve renal function and improve TCM syndromes in patients with stage III diabetes nephropathy with qi yin deficiency syndrome, which should be further promoted.