Clinical analysis of benign epilepsy in children with central temporal spike waves and sleep induced epileptic status epilepticus
儿童良性癫痫伴中央颞区棘波合并睡眠中癫痫性电持续状态的临床分析

摘要

目的 分析左乙拉西坦治疗儿童良性癫痫伴中央颞区棘波并合并睡眠中癫痫性电持续状态的临床效果。方法 观察对象为66例良性癫痫伴中央颞区棘波合并睡眠中癫痫性电持续状态的患儿，收治时间为2024年12月至2025年10月。将其随机分组，采用常规药物治疗的患儿归入X组（n=33），采用左乙拉西坦治疗的患儿归入C组（n=33）。本研究对比C组与X组患儿的脑电活动状况、放电指数、操作智商、预后效果以及不良反应。结果 治疗后，C组α波段、β波段、θ波段、δ波段、放电指数的差值均高于X组（P<0.05）。治疗后，C组操作智商（Performance Intelligence Quotient, PIQ）、言语智商（Verbal Intelligence Quotient, VIQ）、全智商（Full Intelligence Quotient, FIQ）评分显著高于X组（P<0.05）。治疗后，C组治疗总有效率93.94%显著高于X组78.79%（P<0.05）。治疗后，C组不良反应发生率6.06%显著低于X组18.18%（P<0.05）。结论 左乙拉西坦治疗儿童良性癫痫伴中央颞区棘波并合并睡眠中癫痫性电持续状态的临床效果更理想，值得广泛利用。

Abstract

Objective To analyze the clinical effect of levetiracetam in the treatment of benign epilepsy in children with central temporal spike waves and concomitant epileptic status epilepticus during sleep.
Methods The observation subjects were 66 children with benign epilepsy accompanied by central temporal spike waves and sleep onset epileptic electrical continuity. The treatment period was from December 2024 to October 2025. Randomly divide them into two groups: group X (n=33) for children treated with conventional medication, and group C (n=33) for children treated with levetiracetam. This study compared the EEG activity status, discharge index, operational intelligence, prognosis, and adverse reactions between group C and group X.
Results After treatment, the differences in alpha band, beta band, theta band, delta band, and discharge index in group C were higher than those in group X (P<0.05). After treatment, the PIQ, VIQ, and FIQ scores in Group C were significantly higher than those in Group X (P<0.05). After treatment, the total effective rate of Group C was 93.94%, significantly higher than Group X's 78.79% (P<0.05). After treatment, the incidence of adverse reactions in Group C was significantly lower at 6.06% compared to Group X at 18.18% (P<0.05).
Conclusion   Levetiracetam has a more ideal clinical effect in the treatment of benign epilepsy in children with central temporal spikes and concomitant epileptic status epilepticus during sleep, and is worthy of widespread use.