Research on the application effect of risperidone in the treatment of schizophrenia in primary hospitals
利培酮在基层医院精神分裂症治疗中的应用效果研究

摘要

目的 研究对精神分裂症患者应用实施利培酮治疗时所展现的实施价值与实施效果。方法 回顾性分析2025年1月-2025年12月期间在基层医院诊断并开展治疗的精神分裂症患者，共计100例，按入院先后顺序分为对照组与观察组各50例。对照组采用氨磺必利药物治疗，观察组应用利培酮药物治疗，对比两组临床治疗总有效率、精神症状评分及用药依从性。结果 本研究中观察组患者的临床总有效率和用药依从性更高，包括阳性症状、阴性症状、一般精神病理症状及总分在内的临床指标改善情况更好。组间对比差异均有统计学意义（P<0.05）。结论 利培酮应用于基层医院精神分裂症治疗中，能有效改善患者精神症状，提升治疗效果与用药依从性，且药物适配基层临床诊疗特点，安全性与可及性较高，值得在基层医院推广应用。

Abstract

Objective To investigate the implementation value and efficacy of risperidone treatment in patients with schizophrenia.
Methods A retrospective analysis was conducted on 100 schizophrenia patients diagnosed and treated in primary healthcare institutions from January 2025 to December 2025. Patients were divided into a control group (n=50) and an observation group (n=50) based on admission sequence. The control group received aminoglutethimide therapy, while the observation group received risperidone therapy. Clinical outcomes including overall treatment efficacy rate, psychiatric symptom scores, and medication adherence were compared between groups.
Results The observation group demonstrated higher clinical efficacy rates and medication adherence, with significant improvements in positive symptoms, negative symptoms, general psychopathological symptoms, and total symptom scores. All intergroup comparisons showed statistically significant differences (P<0.05).
Conclusion   Risperidone demonstrates efficacy in improving psychiatric symptoms, enhancing treatment outcomes and medication adherence in primary healthcare settings for schizophrenia management. Its compatibility with local clinical practices, high safety profile, and accessibility make it worthy of widespread adoption in primary healthcare institutions.