Observation on the therapeutic effect of intense pulsed laser combined with drug in the treatment of dry eye syndrome before phacoemulsification for cataract
强脉冲激光联合药物治疗白内障超声乳化术前干眼症的疗效观察

摘要

目的 探讨强脉冲激光联合药物治疗在白内障超声乳化术前干眼症患者中的临床应用效果。方法 选取2024年10月-2025年10月于新疆四七四医院拟行白内障超声乳化术的干眼症患者80例，依据随机数字表分组方案，将纳入患者分为对照组和观察组，每组40例，对照组采用玻璃酸钠滴眼液联合睑板腺按摩治疗，观察组在对照组基础上加用强脉冲激光治疗。对比两组患者治疗后泪膜破裂时间（BUT）、基础泪液分泌试验（SIT）、角膜荧光素染色评分及临床症状改善情况。结果 治疗8周后，两组患者BUT、SIT均较治疗前显著升高，角膜荧光素染色评分均较治疗前显著降低，且观察组改善幅度显著优于对照组，差异均有统计学意义（P＜0.05）；观察组治疗总有效率显著高于对照组，差异具有统计学意义（P＜0.05）。结论 强脉冲激光联合药物治疗可有效改善白内障超声乳化术前干眼症患者的睑板腺功能与泪膜稳定性，缓解临床症状，为手术创造良好条件，具有较高的临床推广与应用价值。

Abstract

Objective To explore the clinical application effect of intense pulsed laser combined with drug therapy in patients with dry eye syndrome before phacoemulsification for cataract.
Methods A total of 80 patients with dry eye syndrome who were scheduled to undergo phacoemulsification for cataract in Xinjiang 474 Hospital from October 2024 to October 2025 were selected. According to the random number table grouping scheme, the included patients were divided into the control group and the observation group, with 40 cases in each group. The control group was treated with sodium hyaluronate eye drops combined with meibomian gland massage. The observation group was treated with intense pulsed laser on the basis of the control group. The tear film break-up time (BUT), basic tear secretion test (SIT), corneal fluorescein staining score and improvement of clinical symptoms of the two groups of patients after treatment were compared.
Results After 8 weeks of treatment, the BUT and SIT in both groups were significantly increased compared with those before treatment, and the corneal fluorescein staining scores were significantly decreased compared with those before treatment. Moreover, the improvement amplitude in the observation group was significantly better than that in the control group, and the differences were statistically significant (P < 0.05). The total effective rate of treatment in the observation group was significantly higher than that in the control group, and the difference was statistically significant (P < 0.05).
Conclusion   Intense pulsed laser combined with drug therapy can effectively improve the meibomian gland function and tear film stability of patients with dry eye syndrome before phacoemulsification for cataract, relieve clinical symptoms, create favorable conditions for the surgery, and has high clinical promotion and application value.