Observation on nursing strategies and efficacy of mepolizumab combined with nasal irrigation in patients with chronic rhinosinusitis with nasal polyps
美泊利珠单抗联合鼻腔冲洗对慢性鼻窦炎伴鼻息肉患者的护理策略及疗效观察

摘要

目的 分析美泊利珠单抗联合鼻腔冲洗及个性化护理在慢性鼻窦炎伴鼻息肉患者中的应用效果，为临床诊疗提供循证依据。方法 选取2024年2月-2025年10月我院收治的92例慢性鼻窦炎伴鼻息肉患者，采用随机数字表法分为参照组与研究组，各46例。参照组行常规药物治疗+基础护理，研究组行美泊利珠单抗+鼻腔冲洗+个性化护理，两组干预周期均为12周。对比两组临床疗效、症状缓解时间。结果 研究组临床总有效率（93.5%）高于参照组（76.1%），鼻塞、流涕、头痛症状缓解时间短于参照组，差异均有统计学意义（P＜0.05）；研究组皮肤瘙痒发生率（2.17%）显著低于参照组（21.7%）（P＜0.01），红肿、头痛等不良反应发生率低于参照组，但差异无统计学意义（P＞0.05）。结论 美泊利珠单抗联合鼻腔冲洗及个性化护理的干预模式，可显著提升慢性鼻窦炎伴鼻息肉患者的临床疗效，值得临床推广。

Abstract

Objective To analyze the application effects of mepolizumab combined with nasal irrigation and personalized care in patients with chronic rhinosinusitis with nasal polyps, providing evidence-based guidance for clinical diagnosis and treatment.
Methods A total of 92 patients with chronic rhinosinusitis with nasal polyps admitted to our hospital from February 2024 to October 2025 were selected and randomly divided into a control group and a study group, with 46 cases in each group. The control group received conventional drug therapy and basic nursing care, while the study group received mepolizumab, nasal irrigation, and personalized care. The intervention period for both groups was 12 weeks. Clinical efficacy and symptom relief time were compared between the two groups.
Results The total clinical effective rate of the study group (93.5%) was higher than that of the control group (76.1%). The study group had shorter remission times for symptoms such as nasal congestion, runny nose, and headache compared to the control group, with all differences being statistically significant (P<0.05). The incidence of skin itching in the study group (2.17%) was significantly lower than in the control group (21.7%) (P<0.01). The incidence of adverse reactions such as redness, swelling and headache was lower than that in the control group, but the differences were not statistically significant (P>0.05).
Conclusion   The intervention model of mepolizumab combined with nasal irrigation and personalized care can significantly improve clinical efficacy in patients with chronic rhinosinusitis with nasal polyps and is worthy of clinical promotion.