The effect of lithosperma oil combined with recombinant bovine basic fibroblast growth factor (rb-bFGF) gel on wound healing time and the expression of vascular endothelial growth factor in patients with stage 3-4 pressure injury
紫草油联合重组牛碱性成纤维细胞生长因子（rb-bFGF）凝胶对3-4期压力性损伤患者创面愈合时间及血管内皮生长因子表达的影响

摘要

目的 分析3-4期压力性损伤患者采用紫草油联合重组牛碱性成纤维细胞生长因子凝胶方案治疗对其创面愈合时间以及血管内皮生长因子表达的影响。方法 选取2023年10月至2025年7月期间我院收治的3-4期压力性损伤患者135例，将其随机分为三组，每组各有45例，其中包括对照组采取碘伏消毒，观察一组在碘伏消毒处理后给予rb-bFGF凝胶涂敷创面，观察二组在碘伏消毒处理基础上给予紫草油联合rb-bFGF凝胶，对比分析三组最终取得的治疗效果。结果 治疗后观察二组取得的治疗总有效率显著高于观察一组和对照组，且观察一组治疗有效率高于对照组（P<0.05）；观察二组肉芽组织出现时间以及创口愈合时间均短于观察一组和对照组，且观察一组的所用时间明显短于对照组（P<0.05）；观察二组血管内皮生长因子各指标水平高于观察一组与对照组，且观察一组的血管内皮生长因子各指标水平均高于对照组（P<0.05）。结论 对3-4期压力性损伤患者在常规碘伏消毒处理基础上配合紫草油联合rb-bFGF凝胶，能够进一步提高患者的创面愈合效率，改善患者的血管内皮生长因子表达水平，减轻患者的病痛折磨。

Abstract

Objective To analyze the effects of the treatment regimen of lithosperme oil combined with recombinant bovine basic fibroblast growth factor gel on the wound healing time and the expression of vascular endothelial growth factor in patients with stage 3-4 pressure injuries.
Methods A total of 135 patients with stage 3 to 4 pressure injuries admitted to our hospital from October 2023 to July 2025 were selected and randomly divided into three groups, with 45 cases in each group. Among them, the control group was disinfected with iodophor, and the observation group was treated with rb-bFGF gel applied to the wound surface after iodophor disinfection. Observation Group Two was given lithospermum oil combined with rb-bFGF gel on the basis of iodophor disinfection treatment. The final therapeutic effects achieved by the three groups were compared and analyzed.
Results After treatment, the total effective rate of treatment achieved by Observation Group Two was significantly higher than that of Observation Group One and the control group, and the effective rate of treatment in Observation group One was higher than that in the control group (P<0.05). The appearance time of granulation tissue and the wound healing time in the observation group two were both shorter than those in the observation group one and the control group, and the time taken by the observation group one was significantly shorter than that of the control group (P<0.05). The levels of each index of vascular endothelial growth factor in Observation Group Two were higher than those in Observation Group One and the control group, and the levels of each index of vascular endothelial growth factor in Observation group One were all higher than those in the control group (P<0.05).
Conclusion   For patients with stage 3-4 pressure injuries, in addition to conventional iodophor disinfection treatment, the combination of lithosperms oil and rb-bFGF gel can further improve the wound healing efficiency of patients, enhance the expression level of vascular endothelial growth factor, and alleviate the pain of patients.