Diagnostic value of HP, tumor markers, and HER-2 testing in gastric cancer
HP、肿瘤标记物、HER-2检测在胃癌中的诊断价值

摘要

目的 明确幽门螺杆菌（HP）、血清肿瘤标志物与HER-2联合检测在胃癌诊断中的临床价值。方法 选取60例胃癌患者为观察组，另设60例胃良性病变患者及60例健康体检者为对照组。所有研究对象均行HP抗体分型及血清肿瘤标志物检测，观察组追加术后组织HER-2免疫组化检测，通过ROC曲线分析诊断效能。结果 观察组HP感染率、肿瘤标志物水平及HER-2阳性表达率均显著高于对照组，且肿瘤标志物水平与HER-2阳性率随胃癌分期进展升高。单项检测中CA724诊断效能最优，而三者联合检测的诊断效能显著优于单项检测。结论 HP感染、血清肿瘤标志物异常及HER-2阳性表达均与胃癌发生发展密切相关，三者联合检测可显著提高胃癌诊断效能，尤其对早期胃癌及淋巴结转移的预测具有重要临床价值。

Abstract

Objective To clarify the clinical value of combined detection of Helicobacter pylori (HP), serum tumor markers and HER-2 in the diagnosis of gastric cancer.
Methods Sixty patients with gastric cancer were selected as the observation group, and another 60 patients with benign gastric lesions and 60 healthy individuals undergoing physical examinations were set as the control group. All the research subjects underwent HP antibody typing and serum tumor marker detection. In the observation group, postoperative tissue HER-2 immunohistochemical detection was added, and the diagnostic efficacy was analyzed through ROC curve.
Results The infection rate of HP, the level of tumor markers and the positive expression rate of HER-2 in the observation group were significantly higher than those in the control group. Moreover, the level of tumor markers and the positive rate of HER-2 increased with the progression of gastric cancer stage. Among individual tests, CA724 has the best diagnostic efficacy, while the diagnostic efficacy of the combined detection of the three is significantly better than that of individual tests.
Conclusion   HP infection, abnormal serum tumor markers and positive expression of HER-2 are all closely related to the occurrence and development of gastric cancer. The combined detection of the three can significantly improve the diagnostic efficiency of gastric cancer, especially having important clinical value in the prediction of early gastric cancer and lymph node metastasis.