Study on value of biochemical markers such as urinary NAG, α₁-microglobulin, β₂-microglobulin, transferrin, and serum Cys C in the diagnosis of pediatric kidney injury at different stages
尿液NAG酶、α₁-微球蛋白、β₂-微球蛋白、转铁蛋白及血清Cys C等生化标志物在不同阶段儿童肾损伤诊断中的价值研究

摘要

目的 探讨尿液NAG酶、α₁-MG、β₂-MG、TRF及血清Cys C在不同阶段儿童肾损伤中的诊断价值。方法 选取60例肾损伤患儿（分早、中、晚期组各20例）及20例健康儿童为对照组，检测并比较各组相关指标，分析其诊断效能。结果 肾损伤组各指标水平显著高于对照组，且随损伤加重呈升高趋势；不同指标对各阶段肾损伤诊断优势不同，联合检测各指标对不同阶段肾损伤的诊断效能均显著高于单一指标（P＜0.05）。结论 尿液NAG酶、α₁-MG、β₂-MG、TRF及血清Cys C可有效反映儿童肾损伤程度，联合检测能提高不同阶段肾损伤的诊断准确性，更利于临床早期干预及病情评估。

Abstract

Objective To investigate the diagnostic value of urinary NAG enzyme, α₁-MG, β₂-MG, TRF, and serum Cys C in children with kidney injury at different stages.
Methods A total of 60 children with kidney injury (divided into early, middle, and late stages, 20 cases each) and 20 healthy children as a control group were selected. Relevant indicators were measured and compared among the groups, and their diagnostic efficacy was analyzed.
Results The levels of all indicators in the kidney injury group were significantly higher than those in the control group, and they showed an increasing trend with worsening injury; different indicators had varying diagnostic advantages for different stages of kidney injury, and the combined detection of all indicators had significantly higher diagnostic efficacy for kidney injury at different stages compared to single indicators (P < 0.05).
Conclusion   Urinary NAG enzyme, α₁-MG, β₂-MG, TRF, and serum Cys C can effectively reflect the severity of kidney injury in children. Combined detection can improve the diagnostic accuracy for kidney injury at different stages, which is more favorable for early clinical intervention and disease evaluation.