[email protected]

国际临床研究杂志

International Journal of Clinical Research

您当前位置：首页 > 精选文章

International Journal of Clinical Research. 2026; 10: (3) ; 10.12208/j.ijcr.20260121 .

Analysis of risk factors of postoperative venous thromboembolism in lung cancer patients
肺癌术后患者并发静脉血栓栓塞危险因素分析

作者： 党国信1, 崔晓海2, 孙彤宇1 *

1兵器工业卫生研究所肝胆与血管外科 陕西西安

2西安交通大学第一附属医院胸外科 陕西西安

*通讯作者： 孙彤宇,单位：兵器工业卫生研究所肝胆与血管外科 陕西西安; ；

引用本文: 党国信, 崔晓海, 孙彤宇 肺癌术后患者并发静脉血栓栓塞危险因素分析[J]. 国际临床研究杂志, 2026; 10: (3) : 23-26.
Published: 2026/3/28 9:25:32

摘要

目的 探讨肺癌术后并发静脉血栓栓塞的高危因素。方法 收集2024年8月-2025年8月在西安交通大学第一附属医院胸外科接受肺癌手术治疗的150例患者的临床资料。根据术后有无并发静脉血栓栓塞将所有患者分为静脉血栓栓塞组30例和无静脉血栓栓塞组120例。回顾性分析患者的临床资料，比较两组患者在一般资料、术前辅助检查结果、手术相关因素、术后病理相关因素等方面的差异。采用多因素logistic回归分析肺癌术后并发静脉血栓栓塞的危险因素。结果 两组患者在年龄、术前CEA水平、D-二聚体、白细胞、红细胞、肺功能水平、手术方式、手术范围、手术时间、术中出血量等方面差异有统计学意义（P＜0.05）；多因素Logistic回归分析结果显示，术前D-二聚体水平、红细胞水平、FEV1水平、手术方式、手术时间是肺癌术后患者并发静脉血栓栓塞的独立危险因素（P＜0.05）。结论 术前D-二聚体水平升高、红细胞水平降低、FEV1水平降低、开胸手术、手术时间较长的肺癌患者手术后易发生静脉血栓栓塞。

关键词： 肺癌；静脉血栓栓塞；高危因素；D-二聚体

Abstract

Objective To explore the risk factors of postoperative venous thromboembolism in lung cancer patients.
Methods The clinical data of 120 lung cancer patients who underwent surgery in our hospital from August 2024 to August 2025 were collected. 150 lung cancer patients who underwent surgery were divided into venous thromboembolism group (n=30) and non-venous thromboembolism group (n=120) according to whether venous thromboembolism occurred after operation. The clinical data of the patients were retrospectively analyzed. And the differences between the two groups in general data, preoperative auxiliary examination results, operative related factors and postoperative pathological related factors were compared. Multivariate logistic regression was used to analyze the risk factors of postoperative venous thromboembolism of the two groups of patients.
Results There were significant differences in age, preoperative CEA levels, preoperative D-dimer levels, white blood cell count, red blood cell count, lung function levels, surgical procedures, surgical scope, operation time and blood loss between the two groups (P＜0.05). Logistic regression analysis showed that preoperative D-dimer levels, red blood cell count, forced expiratory volume in one second (FEV1), surgical procedures and operation time were independent risk factors for postoperative venous thromboembolism in lung cancer patients.
Conclusion  s The lung cancer patients who were with higher levels of preoperative D-dimer, lower red blood cell count, lower levels of FEV1, open thoracotomy and longer operation time are prone to venous thromboembolism after surgery.

Key words： Lung cancer; Venous thromboembolism; Risk factors; D-dimer

参考文献 References

[1] Yang R, Wang H, Liu D, et al. Incidence and risk factors of VTE in lung cancer: a meta-analysis[J]. Ann Med. 2024 ,56(1):2390200. 

[2] Mørkved AL, Søgaard M, Skjøth F, et al. Risk and Timing of Venous Thromboembolism After Surgery for Lung Cancer: A Nationwide Cohort Study[J]. Ann Thorac Surg. 2024 ,117(2):289-296. 

[3] 李莉,周培华,薛翔,等.中国肺癌术后静脉血栓栓塞发生的Meta分析[J].中国临床研究,2022,35(05):627-631.

[4] 李辉.《中国胸部恶性肿瘤围手术期静脉血栓栓塞症预防与管理指南（2022版）》解读[J].中国胸心血管外科临床杂志,2022,29(10):1239-1242.

[5] Van Cutsem E, Mahé I, Felip E, et al. Treating cancer-associated venous thromboembolism: A practical approach[J]. Eur J Cancer. 2024 ,209:114263. 

[6] Björklund J, Rautiola J, Zelic R, et al. Risk of Venous Thromboembolic Events After Surgery for Cancer[J]. JAMA Netw Open. 2024 ,7(2): e2354352. 

[7] Saad M, Batool RM, Waqas SA, et al. Unveiling the trends: Growing cancer and venous thromboembolism mortality in older adults in the United States, 1999-2020[J]. Thromb Res. 2025,247:109259. 

[8] Pastori D, Cormaci VM, Marucci S, et al. A Comprehensive Review of Risk Factors for Venous Thromboembolism: From Epidemiology to Pathophysiology[J]. Int J Mol Sci. 2023 ,4(4):3169. 

[9] Stuby J, Haschke M, Tritschler T, et al. Oral anticoagulant therapy in older adults[J]. Thromb Res. 2024 ,238:1-10.

[10] Takahashi K, Yamashita Y, Morimoto T, et al. Age and long-term outcomes of patients with venous thromboembolism: From the COMMAND VTE Registry[J]. Int J Cardiol. 2023,383:89-95.

[11] Tøndel BG, Morelli VM, Hansen JB, et al. Risk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review[J]. J Thromb Haemost. 2022,20(10):2173-2186. 

[12] Baskurt OK, Meiselman HJ. Blood Rheology and Hemodynamics[J]. Semin Thromb Hemost. 2024,50(6): 902-915.

[13] 黎苏,汪玲玲,霍虹,等.肺癌患者静脉血栓栓塞症的危险因素分析及预防现状[J].中国医院药学杂志,2019, 39(13):1395-1400.

[14] Falanga A, Marchetti M. Cancer-associated thrombosis: enhanced awareness and pathophysiologic complexity[J]. J Thromb Haemost. 2023 ,21(6):1397-1408.

[15] Cohen O, Caiano LM, Levy-Mendelovich S. Cancer-associated splanchnic vein thrombosis: Clinical implications and management considerations[J]. Thromb Res. 2024, 234:75-85.