The effect of nicardipine versus nifedipine on postpartum hypertensive emergencies in severe preeclampsia
尼卡地平对比硝苯地平对重度子痫前期产后高血压急症的影响

摘要

目的 分析重度子痫前期产后高血压急症使用尼卡地平和硝苯地平的效果。方法 选取2023年5月至2025年1月收治的114例重度子痫前期产后高血压急症患者，随机择57例接受硝苯地平治疗（对照组），另57例采用尼卡地平治疗（观察组）。观察不同疗法效果，对比治疗方法对持续收缩压（SBP）、舒张压（DBP）、24h尿蛋白（24hUpro）、血清NO，ET-1水平影响，记录两组并发症情况。结果 治疗后，观察组疗效率较对照组高，差异性显著（P<0.05）。治疗前各项治疗指标组间对比（P >0.05）；治疗后，观察组SBP、DBP、24hUpro、ET-1降低幅度较大，且其血清NO水平显著提升，组间对比差异性显著（P<0.05）。观察组并发症率低于对照组（3.51%VS19.30%），差异显著（P<0.05）。结论 与硝苯地平治疗相比，尼卡地平改善高血压状态效果明显，疗效提升且安全性高，值得在该疾病患者中推广使用。

Abstract

Objective To analyze the effect of nicardipine and nifedipine in postpartum hypertensive emergencies with severe preeclampsia.
Methods A total of 114 patients with severe preeclampsia and postpartum hypertensive emergencies admitted from May 2023 to January 2025 were selected. 57 cases were randomly treated with nifedipine (control group), and the other 57 cases were treated with nicardipine (observation group). Observe the effects of different therapies, compare the influences of treatment methods on sustained systolic blood pressure (SBP), diastolic blood pressure (DBP), 24-hour urine protein (24hUpro), serum NO and ET-1 levels, and record the complications of the two groups.
Results After the nursing care, the therapeutic effect rate of the observation group was higher than that of the control group, with a significant difference (P<0.05). Comparison of various treatment indicators between groups before nursing (P >0.05); After treatment, the levels of SBP, DBP, 24hUpro and ET-1 in the observation group decreased significantly, and the serum NO level increased significantly. There was a significant difference between the groups (P<0.05). The complication rate of the observation group was lower than that of the control group (3.51% vs 19.30%), and the difference was significant (P<0.05).
Conclusion   Compared with nifedipine treatment, nicardipine has a significant effect in improving the hypertensive state, with enhanced efficacy and high safety. It is worthy of promotion and application in patients with this disease.