Effect of transcranial magnetic stimulation combined with olanzapine on auditory hallucination and cognitive impairment in schizophrenia
经颅磁刺激联合奥氮平治疗精神分裂症幻听的疗效及对认知障碍的影响

摘要

目的 对精神分裂症幻听疾病实际治疗中，研究经颅磁刺激联合奥氮平的具体影响。方法 调查就诊2023年6月至2024年6月来自襄阳市安定医院的78例精神分裂症且存在幻听症状的患者，分组经随机数字法分为奥氮平、rTMS联合奥氮平的对照组和观察组，每组例数为39例，比较各项指标。结果 组别之间对比PANSS量表、WMS评分均未见一定差异（P>0.05），而治疗后各项结果可见（P<0.05），其中观察组的PANSS量表分值更低，且观察组的WMS评分更高；而总有效率在组间比较，仍体现结果的差异性价值（P<0.05），其中观察组的总有效率更高。结论 为保证精神分裂症幻听患者病情更稳定，建议联合使用经颅磁刺激、奥氮平，有利于患者认知障碍改善。

Abstract

Objective To investigate the specific effects of transcranial magnetic stimulation (rTMS) combined with olanzapine in the clinical treatment of auditory hallucinations in schizophrenia.
Methods A total of 78 patients with schizophrenia and auditory hallucinations symptoms, who visited Xiangyang Anding Hospital from June 2023 to June 2024, were enrolled. They were randomly divided into an olanzapine group, an rTMS combined with olanzapine control group, and an observation group, with 39 cases in each group. All indicators were compared.
Results No significant differences were observed between groups in the PANSS scale and WMS scores (P>0.05). However, post-treatment results showed significant differences (P<0.05), with the observation group achieving lower PANSS scores and higher WMS scores. The overall response rate also demonstrated significant intergroup differences (P<0.05), with the observation group showing a higher overall response rate.
Conclusion   To ensure the more stable condition of patients with schizophrenia auditory hallucination, it is suggested to use transcranial magnetic stimulation and olanzapine in combination, which is beneficial to the improvement of patients’ cognitive impairment.