Correlation analysis of TCM syndrome types and risk factors and clinical pathological factors in colorectal cancer
探究结直肠癌中医证型与风险因素和临床病理相关性分析

摘要

目的 探索结直肠癌中医证型与风险因素及临床病理因素的相关性，旨在深化对结直肠癌病理机制的理解，并提供针对性更强的中西医结合治疗策略。方法 与河北华奥医院及中国人民解放军陆军第八十一集团军医院的肿瘤科、胃肠外科、病理科等相关科室建立联系，筛选符合条件的结直肠癌患者。建立结直肠癌患者中医证型与风险因素的关联数据库：收集并分析结直肠癌患者的全面数据，包括基本信息、生活习惯、术后病理资料等。系统分析中医证型与临床病理特征的相关性。结果 本次研究共纳入结直肠癌患者323例，其中男性186例，占总病例数的57.59%；女性137例，占总病例数的42.41%。所有患者中最小年龄28岁，最大年龄89岁，其中＜60岁149例（46.13%），≥60岁174例（53.87%），平均年龄（62.5±7.04）岁。结直肠癌患者中有吸烟史的患者有88例，占总病例数的27.24%；有饮酒史的患者有125例，占总病例数的38.70%；既有吸烟史，又有饮酒史的有64例，占总病例数的19.81%。在中医证型分布中，从占病例比高低分别为湿热蕴结证121例（37.46%），气滞血瘀证68例（21.05%），气血两虚证52例（16.10%），脾肾阳虚证47例（14.55%），肝肾阴虚证35例（10.84%）。通过分析323例结直肠癌患者的中医证型与患者的性别、年龄、吸烟史、病理组织学分型方面差异无明显统计学差异（P＞0.05）；在饮酒史、肿瘤TNM分期、淋巴结转移方面具有统计学差异（P＜0.05）。结论 结直肠癌患者中医证型以湿热蕴结证较多见，肝肾阴虚证相对出现频率较低，中医证型分布与饮酒史、肿瘤TNM分期、淋巴结转移之间具有明显相关性，为结直肠癌的中医诊断、治疗和预防提供参考依据，值得推广。

Abstract

Objective To explore the correlation between TCM syndrome types and risk factors and clinical pathological factors in colorectal cancer, aiming to deepen the understanding of the pathological mechanism of colorectal cancer and provide more targeted integrated traditional Chinese and Western medicine treatment strategies.
Methods Establish contact with the oncology, gastrointestinal surgery, and pathology departments of Hebei Huaao Hospital and the 81st Group Army Hospital of the People's Liberation Army of China to screen eligible colorectal cancer patients. Establish a database of the correlation between TCM syndrome types and risk factors in colorectal cancer patients: collect and analyze comprehensive data of colorectal cancer patients, including basic information, lifestyle habits, and postoperative pathological data. Systematically analyze the correlation between TCM syndrome types and clinical pathological characteristics.
Results In the distribution of TCM syndrome types, the cases from high to low were damp-heat accumulation syndrome (121 cases, 37.46%), qi stagnation and blood stasis syndrome (68 cases, 21.05%), qi and blood deficiency syndrome (52 cases, 16.10%), spleen-kidney yang deficiency syndrome (47 cases, 14.55%), and liver-kidney yin deficiency syndrome (35 cases, 10.84%). Through the analysis of 323 colorectal cancer patients, there was no significant statistical difference in the TCM syndrome types and the patients' gender, age, smoking history, and pathological histological classification (P > 0.05); there were significant statistical differences in drinking history, tumor TNM stage, and lymph node metastasis (P < 0.05).
Conclusion   Among patients with colorectal cancer, the syndrome of dampness-heat accumulation is more frequently observed in traditional Chinese medicine (TCM), while the syndrome of liver-kidney yin deficiency occurs less frequently. The distribution of TCM syndromes is significantly correlated with alcohol consumption history, tumor TNM stage, and lymph node metastasis, providing a reference basis for the diagnosis, treatment, and prevention of colorectal cancer in TCM and is worthy of promotion.