Clinical study on the effective reduction of hypoxemia in patients with coronary heart disease undergoing painless gastroscopy using nasal high flow oxygen therapy
经鼻高流量氧疗在冠心病患者进行无痛胃肠镜检查中有效减少低氧血症发生的临床研究

摘要

目的 探讨经鼻高流量氧疗在冠心病患者无痛胃肠镜检查中减少低氧血症发生的临床应用效果。方法 选择2023年5月至2025年5月期间本院行无痛胃肠镜检查的60例冠心病患者，采用随机数字表法分为高流量组和常规组，各30例。胃肠镜检查期间，常规组常规鼻导管吸氧，高流量组实施经鼻高流量氧疗，观察两组血氧饱和度（SpO₂）变化，并对比两组低氧血症发生率及中断检查率。结果 高流量组麻醉后5min、麻醉后10min、胃肠镜检查完毕、术毕5min患者SpO2水平显著高于常规组（P<0.05）。高流量组术中低氧血症发生率（0）显著低于常规组（16.67%）（P<0.05）。高流量组中断检查率（0）与常规组（3.33%）比较，差异无统计学意义（P＞0.05）。结论 冠心病患者无痛胃肠镜检查中采用经鼻高流量氧疗模式，可更好地维持SpO2水平，并可有效减少低氧血症发生率，有助于提升该类患者无痛胃肠镜检查安全性。

Abstract

Objective Exploring the clinical application effect of nasal high flow oxygen therapy in reducing hypoxemia during painless gastroscopy in patients with coronary heart disease.
Methods Sixty patients with coronary heart disease who underwent painless gastroscopy in our hospital from May 2023 to May 2025 were randomly divided into a high flow group and a conventional group, with 30 patients in each group, using a random number table method. During gastroscopy, the routine group received routine nasal cannula oxygen therapy, while the high flow group received nasal high flow oxygen therapy. The changes in blood oxygen saturation (SpO₂) between the two groups were observed, and the incidence of hypoxemia and interruption of examination were compared between the two groups.
Results The SpO2 levels in the high flow group were significantly higher than those in the conventional group at 5 minutes after anesthesia, 10 minutes after anesthesia, 5 minutes after completion of gastroscopy, and 5 minutes after surgery (P<0.05). The incidence of intraoperative hypoxemia in the high flow group (0) was significantly lower than that in the conventional group (16.67%) (P<0.05). The interruption rate of the high traffic group (0) was not significantly different from that of the conventional group (3.33%) (P>0.05).
Conclusion   The use of high flow oxygen therapy through the nose during painless gastroscopy in patients with coronary heart disease can better maintain SpO2 levels and effectively reduce the incidence of hypoxemia, which helps to improve the safety of painless gastroscopy in such patients.