Clinical effect of rutin combined with puerarin in treating pediatric purpura nephritis
雷公藤多苷联合葛根素治疗小儿紫癜性肾炎的临床效果观察

摘要

目的 小儿紫癜性肾炎是一种常见的继发性肾小球疾病，需给予科学有效的治疗，因此本文探讨雷公藤多苷联合葛根素治疗小儿紫癜性肾炎的临床效果。方法 对我院收治的小儿紫癜性肾炎患者进行深入研究，对比不同治疗方案下两者患者治疗效果。结果 观察组临床治疗有效率为93.75%，对照组为80.49%，观察组IgA、IgM和TNF-α水平显著低于对照组，IgG、IL-10水平显著高于对照组，观察24h尿蛋白定量和24h尿红细胞计数均显著低于对照组，P＜0.05说明存在对比意义。结论 雷公藤多苷联合葛根素治疗小儿紫癜性肾炎，能够有效下调炎症因子，改善免疫功能和肾功能，提高临床疗效。

Abstract

Objective Henoch-Schönlein purpura nephritis (HSPN), a common secondary glomerular disorder in children, requires scientifically validated treatment strategies. This study investigated the clinical efficacy of Tripterygium wilfordii polysaccharide combined with Puerarin in managing HSPN.
Methods A comprehensive analysis was conducted on pediatric HSPN patients treated at our hospital, comparing outcomes between different therapeutic regimens.
Results The observation group achieved a clinical response rate of 93.75%, compared to 80.49% in the control group. Significant differences were observed in IgA, IgM, and TNF-α levels between the groups, while IgG and IL-10 levels were markedly higher. Both 24-hour urine protein quantification and red blood cell count showed statistically significant lower values in the observation group (P<0.05).
Conclusion   The combination therapy of Tripterygium wilfordii polysaccharide and Puerarin effectively reduces inflammatory factors, improves immune function and renal function, thereby enhancing clinical outcomes in HSPN management.