Clinical efficacy and safety of Aftanetine and propofol composite sedation anesthesia in TherapeuticCP
阿芬太尼复合丙泊酚镇静麻醉在治疗性ERCP术中的临床效果及安全性研究

摘要

目的 探析治疗性ERCP术中行阿芬太尼、丙泊酚镇静麻醉的价值。方法 2024年8月-2025年8月，取我院接受治疗性ERCP的170例患者，170例患者术前0.5h均给予山莨菪碱 10 mg、哌替啶 50 mg，以数表法随机分组，各组均85例，对照组选择清醒状态下执行手术，将丙泊酚、阿芬太尼给予观察组，诱导镇静后开始手术，期间丙泊酚、阿芬太尼持续泵入，对比两组血流动力学、观察指标等。结果 置镜时，观察组血流动力学均较对照组更优，观察指标均较对照组更佳， 安全性较对照组更高（P<0.05）；麻醉前、术后2h，组间MMSE评分对比（P>0.05）。结论 治疗性ERCP术中开展丙泊酚、阿芬太尼麻醉所获疗效较好，值得借鉴。

Abstract

Objective To explore the value of Aftanetine and Propofol sedation anest in therapeutic ERCP surgery.
Methods From August 2024 to August 2025, 170 patients who received therapeutic ERCP in our hospital selected. All 170 patients were given 10 mg of hyoscyamine and 50 mg of pethidine 0.5 h before the operation The patients were randomly divided into groups by the random number table method, each group had 85 cases, the control group chose to perform the operation under the awake state, the Propofol and Aftanetine were given to the observation group, and the operation began after induction of sedation. During the operation, Propofol and Aanetine were continuously infused. The hemodynamic, observation indexes and other data of the two groups were compared.
Results At the time of lens placement, the hemodynamic of observation group was better than that of the control group, and the observation indexes were better than those of the control group, and the safety was higher than that of the control group ( <0.05); Before and after anesthesia, the MMSE scores were compared between groups (P > 0.05).
Conclusion   The cur effect of Propofol and Aftanetine anesthesia in therapeutic ERCP surgery is relatively good and worth learning from.