Observational study on the clinical efficacy of Niuhuang Shedan Chuanbei drop pill combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution hydrochloride and clenbuterol hydrochloride oral solution in the treatment of cough and phlegm
牛黄蛇胆川贝滴丸联合氨溴特罗止咳化痰的临床疗效观察

摘要

目的 评估牛黄蛇胆川贝滴丸联合氨溴特罗止咳化痰的临床疗效。方法 研究共纳入96例患者，将患者随机分为两组，一组为对照组，另一组为实验组。对照组口服氨溴特罗口服液治疗，而实验组则同时使用牛黄蛇胆川贝滴丸和氨溴特罗口服液进行治疗，治疗周期设定为7天。治疗前后的中医证候评估指标被用以评价临床效果，此外肺功能指标FEV₁/FVC和FEV₁/pred比值也被用于评估临床疗效。结果 治疗结束后，两组患者的中医证候评分及其总分都呈现出了明显的降低。其中，对照组和实验组的临床治疗总有效率分别66.7%和95.8%，经过卡方检验分析，治疗组与对照组之间存在显著差异（p<0.01）。与对照组相比，治疗组在中医证候的主症和次症方面均有显著性改善（p<0.01）；肺功能指标FEV₁/FVC和FEV₁/pred比值也有显著性提高（p<0.05或p<0.01）。结论 牛黄蛇胆川贝滴丸联合氨溴特罗在临床上具有良好的止咳化痰疗效。

Abstract

Objective To evaluate the clinical efficacy of Niuhuang Shedan Chuanbei Drop Pill combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution for the treatment of cough and phlegm.
Methods A total of 96 patients were included in the study and randomly assigned to a control group and a treatment group. The control group was treated with ambroxol hydrochloride and clenbuterol hydrochloride oral solution oral solution, while the treatment group was given Niuhuang Shedan Chuanbei Drop Pill combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution oral solution for a treatment period of 7 days. Traditional Chinese medicine (TCM) syndrome evaluation indicators before and after treatment were used to assess the clinical effects. In addition, the FEV₁/FVC and FEV₁/pred ratios of pulmonary function were also used to evaluate the clinical efficacy.
Results After treatment, the TCM syndrome scores and their sums decreased significantly in both groups; the total clinical effective rates were 66.7% and 95.8% respectively, and the difference was statistically significant (p<0.01) by chi-square test analysis; compared to the control group, the treatment group showed significant improvements in the primary and secondary symptoms of TCM syndrome (p<0.01); the FEV₁/FVC and FEV₁/pred ratios of pulmonary function also significantly increased (p<0.05 or p<0.01).
Conclusion   Niuhuang Shedan Chuanbei Drop Pill combined with ambroxol hydrochloride and clenbuterol hydrochloride oral solution shows good clinical efficacy in treating cough and phlegm.