[email protected]

国际临床研究杂志

International Journal of Clinical Research

您当前位置：首页 > 精选文章

International Journal of Clinical Research. 2025; 9: (11) ; 10.12208/j.ijcr.20250555 .

Clinical observation of the efficacy of benazepril and amlodipine tablets combined with telmisartan in the treatment of hypertension in the elderly
苯磺酸左氨氯地平片联合替米沙坦治疗老年高血压的临床疗效观察

作者： 何萌 *

上海市奉贤区柘林镇社区卫生服务中心 上海

*通讯作者： 何萌,单位：上海市奉贤区柘林镇社区卫生服务中心 上海；

引用本文: 何萌 苯磺酸左氨氯地平片联合替米沙坦治疗老年高血压的临床疗效观察[J]. 国际临床研究杂志, 2025; 9: (11) : 173-175.
Published: 2025/11/25 11:51:32

摘要

目的 探讨苯磺酸左氨氯地平片联合替米沙坦治疗老年高血压患者的临床疗效及安全性。方法 在我院2023年1月至2024年1月选取100例老年高血压患者，将其以治疗方式为参考分组，且每组50例。分别给予苯磺酸左氨氯地平片单药治疗（对照组），苯磺酸左氨氯地平片联合替米沙坦治疗（观察组），两组均持续治疗12周后判定区别治疗效果。结果 治疗12周后，两组 SBP、DBP 均较治疗前显著降低（P<0.05），且观察组SBP（132.5±7.8 mmHg）、DBP（82.3±5.6 mmHg）均低于对照组（145.2±8.5 mmHg、89.6±6.1 mmHg）（P<0.05）。观察组治疗总有效率（94.00%）显著高于对照组（78.00%）（P<0.05）。两组不良反应发生率比较（观察组 8.00% vs 对照组 10.00%）（P>0.05）。结论 苯磺酸左氨氯地平片联合替米沙坦治疗老年高血压可更有效降低血压，提升临床疗效，且安全性良好，适合老年患者长期应用。

关键词： 老年高血压；苯磺酸左氨氯地平片；替米沙坦；联合用药；血压控制

Abstract

Objective To explore the clinical efficacy and safety of levamlodipine besylate tablets combined with telmisartan in the treatment of elderly patients with hypertension.
Methods From January 2023 to January 2024, 100 elderly patients with hypertension were selected in our hospital and grouped according to the treatment methods, with 50 cases in each group. The two groups were respectively treated with levamlodipine besylate tablets as monotherapy (control group) and levamlodipine besylate tablets combined with telmisartan (observation group). The therapeutic effects of the two groups were determined after continuous treatment for 12 weeks.
Results After 12 weeks of treatment, the SBP and DBP in both groups were significantly lower than those before treatment (P<0.05). Moreover, the SBP (132.5±7.8 mmHg) and DBP (82.3±5.6 mmHg) in the observation group were both lower than those in the control group (145.2±8.5 mmHg, 89.6±6.1 mmHg) (P<0.05). The total effective rate of treatment in the observation group (94.00%) was significantly higher than that in the control group (78.00%) (P<0.05). Comparison of the incidence of adverse reactions between the two groups (observation group 8.00% vs control group 10.00%) (P>0.05).
Conclusion   The combination of levamlodipine besylate tablets and telmisartan in the treatment of elderly hypertension can more effectively lower blood pressure, improve clinical efficacy, and has good safety. It is suitable for long-term application in elderly patients.

Key words： Hypertension in the elderly; Levamlodipine besylate; Tablets Telmisartan; Combination therapy; Blood pressure control

参考文献 References

[1] 鞠宏丽. 苯磺酸左氨氯地平片联合替米沙坦片治疗高血压患者的临床价值[J]. 中国药物经济学,2021,16(2): 70-72,79. 

[2] 薛乔乔,杨欢. 苯磺酸左氨氯地平片联合替米沙坦片用于治疗高血压的药效分析[J]. 家庭药师,2023,16(2):65-67. 

[3] 李平飞,廖纪华. 苯磺酸左氨氯地平片联合替米沙坦片治疗高血压病的临床价值[J]. 心电图杂志（电子版）, 2020,9(3):244-245.

[4] 蔡由富. 苯磺酸左旋氨氯地平片治疗高血压的临床效果观察[J]. 特别健康,2021(18):17-18.

[5] 焦亮. 苯磺酸氨氯地平片治疗高血压临床效果分析[J]. 饮食保健,2021(15):65.

[6] 祁承龙. 酒石酸美托洛尔缓释片联合苯磺酸氨氯地平片治疗高血压合并慢性心力衰竭的临床效果[J]. 河南医学研究,2021,30(2):298-300. 

[7] 王鸿权. 苯磺酸氨氯地平片联合酒石酸美托洛尔片对老年晨峰高血压合并冠心病患者血压变异性、血压晨峰现象的影响[J]. 检验医学与临床,2024,21(3):363-367. 

[8] 史明甦. 苯磺酸氨氯地平联用美托洛尔治疗老年原发性高血压的临床观察[J]. 中国现代药物应用,2024, 18(21): 96-98.

[9] 郏战涛,程帅师,王飞.硝苯地平控释片联合替米沙坦片治疗老年冠心病合并顽固性高血压的效果分析[J].中国实用医刊,2022,49(12):98-101.

[10] 黄文海,邱卫东,杨志强,等. 苯磺酸左氨氯地平片联合厄贝 沙坦对老年难治性高血压患者血压水平及炎症反应的影 响[J].现代医学与健康研究(电子版),2023,7(14): 142-144.