The effect of sevoflurane combined anesthesia on stress response and hemodynamic analysis during laparoscopic cholecystectomy
七氟醚复合麻醉对腹腔镜胆囊摘除术中应激反应的影响及血流动力学分析

摘要

目的 探讨七氟醚复合麻醉在腹腔镜胆囊摘除术中对患者应激反应及血流动力学参数的影响。方法选取2023年1月至2025年6月行腹腔镜胆囊摘除术的患者120例，随机分为观察组（七氟醚复合瑞芬太尼麻醉）和对照组（丙泊酚复合瑞芬太尼麻醉）。监测两组患者麻醉前、术毕及拔管时的血清皮质醇（Cor）、去甲肾上腺素（NE）、心率（HR）及平均动脉压（MAP）水平。结果 观察组T1、T2时刻的Cor、NE、HR及MAP水平均显著低于对照组，差异具有统计学意义（P＜0.05）。两组患者T0时各项指标无显著差异（P＞0.05）。结论 七氟醚复合麻醉能够更有效地抑制腹腔镜胆囊摘除术中的应激反应，维持血流动力学稳定性，可能为临床优化麻醉方案提供参考。

Abstract

Objective To investigate the effects of sevoflurane combined anesthesia on stress response and hemodynamic parameters in patients undergoing laparoscopic cholecystectomy.
Methods 120 patients who underwent laparoscopic cholecystectomy from January 2023 to June 2025 were randomly divided into an observation group (anesthesia with sevoflurane combined with remifentanil) and a control group (anesthesia with propofol combined with remifentanil). Monitor the serum cortisol (Cor), norepinephrine (NE), heart rate (HR), and mean arterial pressure (MAP) levels of two groups of patients before anesthesia, after surgery, and during extubation.
Results The levels of Cor, NE, HR, and MAP in the observation group at T1 and T2 were significantly lower than those in the control group, and the differences were statistically significant (P<0.05). There was no significant difference in various indicators between the two groups of patients at T0 (P>0.05).
Conclusion   Sevoflurane combined anesthesia can more effectively suppress stress response during laparoscopic cholecystectomy, maintain hemodynamic stability, and may provide reference for optimizing anesthesia plans in clinical practice.