International Research in Chinese Medicine
International Research in Chinese Medicine. 2025; 5: (2) ; 10.12208/j.ircm.20250017 .
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1 弥勒市中医医院 云南弥勒
2 云南省中医中药研究院 云南昆明
*通讯作者： 田春洪,单位： 云南省中医中药研究院 云南昆明；
目的 观察国医大师张震疏调解郁汤治疗抑郁症的临床疗效。方法 采用随机对照的设计，将72例患者随机分成观察组36例（疏调解郁汤组）和对照组36例（草酸艾司西酞兰），2组均治疗6周后，观察比较2组患者治疗前后进行汉密尔顿抑郁量表（HAMD-24项）评分､抑郁自评量表（SDS）量表评分､匹兹堡睡眠质量指数（PSQI）评分及中医证候积分评分。结果 治疗组总有效率为94.4%，对照组总有效率为77.7%，2组总有效率比较差异有统计学意义（P<0.05）；2组患者中医伴随症状积分治疗后较治疗前均有明显改善，治疗组改善情况明显优于对照组，差异均有统计学意义（P<0.05）。结论 国医大师张震疏调解郁汤治疗抑郁症效果显著，值得临床推广应用。
Objective To observe the clinical efficacy of Zhang Zhenshu, a master of traditional Chinese medicine, in the treatment of depression with the Qiaoyu Decoction. Methods A randomized controlled design was adopted. 72 patients were randomly divided into an observation group of 36 cases (Shujiang Zhongyu Decoction group) and a control group of 36 cases (escitalilam oxalate). After 6 weeks of treatment for both groups, the scores of the Hamilton Depression Scale (HAMD-24 items), the Self-Rating Depression Scale (SDS), and the Pittsburgh Sleep Quality before and after treatment were observed and compared between the two groups Quantitative Index (PSQI) score and TCM Syndrome score. Results The total effective rate was 94.4% in the treatment group and 77.7% in the control group. There was a statistically significant difference in the total effective rate between the two groups (P<0.05). Both groups of patients showed significant improvement after treatment with the TCM concomitant symptom score compared with that before treatment. The improvement in the treatment group was significantly better than that in the control group, and the differences were statistically significant (P<0.05). Conclusion The National Master of Traditional Chinese Medicine, Zhang Zhenshu, has a remarkable therapeutic effect on depression and is worthy of clinical promotion and application.
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