Effects of lithium carbonate combined with olanzapine treatment on metabolic indicators in patients with bipolar disorder
碳酸锂联合奥氮平治疗对双相情感障碍患者代谢指标的影响

摘要

目的 明确双相情感障碍患者中施以碳酸锂联合奥氮平治疗方式的价值。方法 以2024年7月至2025年7月期间院内临床综合诊断为双相情感障碍的69例患者作为试验观察对象，试验分组按照随机数字表法进行，包括对照组（34例）、观察组（35例），不同小组治疗模式分别以常规手段、碳酸锂联合奥氮平手段开展，分析比较其结果。结果 经组间数据比较，治疗后对比的对象之间结果P<0.05，表现出显著差异，代谢指标方面表示观察组更趋于正常水平，躁狂与抑郁症状方面表示观察组更轻。结论 于双相情感障碍患者中施以碳酸锂联合奥氮平治疗方式，对减轻临床症状有着重要意义，有助于稳定糖脂代谢指标。

Abstract

Objective To clarify the value of lithium carbonate combined with olanzapine treatment in patients with bipolar disorder.
Methods 69 patients with clinical comprehensive diagnosis of bipolar disorder in the hospital from July 2024 to July 2025 were used as the test observation objects. The test groups were carried out according to the randomized digital table method, including the control group (34 cases) and the observation group (35 cases). The treatment modes of different groups were carried out by conventional means and lithium carbonate combined with olanzapine methods, and the results were analyzed and compared.
Results Compared with the data between groups, the results between the subjects compared after treatment showed a significant difference of P<0.05. In terms of metabolic indicators, the observation group was more normal, and manic and depressive symptoms showed that the observation group was lighter.
Conclusion   The treatment of lithium carbonate combined with olanzapine in patients with bipolar disorder is of great significance for alleviating clinical symptoms and helps to stabilize glycolipid metabolism indicators.