International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (8) ; 10.12208/j.ijcr.20250374 .
总浏览量: 122
1 山西医科大学 山西太原
2 山西医科大学第一医院妇科 山西太原
*通讯作者： 翟瑞芳,单位： 山西医科大学第一医院妇科 山西太原；
目的 探讨丝素蛋白凝胶敷料治疗高危型人乳头瘤病毒感染合并妇科炎症的研究。方法 选择我院2024年1月-2024年12月期间收治的高危型人乳头瘤病毒感染合并妇科炎症患者150例，将其按随机分组方法分为对照组（75例，采用乳酸菌阴道胶囊治疗方法）和试验组（75例，采用丝素蛋白凝胶敷料治疗），对两组临床治疗效果、炎症因子水平、HPV转阴情况以及阴道微生态情况（阴道pH值，Nugent评分）进行对比与评估。结果 试验组各项炎症因子水平均低于对照组（P＜0.05）。试验组患者阴道pH值，Nugent评分均低于对照组（P＜0.05）。试验组HPV转阴率和临床治疗有效率均高于对照组（P＜0.05）。结论 在对高危型人乳头瘤病毒感染合并妇科炎症患者实施丝素蛋白凝胶敷料治疗取得明显效果，可显著提高患者HPV转阴率，降低炎症反应，改善阴道微生态，有较高临床应用价值。
Objective To explore the study of silk fibroin gel dressings in the treatment of high-risk human papillomavirus infection complicated with gynecological inflammation. Methods A total of 150 patients with high-risk human papillomavirus infection complicated with gynecological inflammation who were admitted to our hospital from January 2024 to December 2024 were selected and randomly divided into the control group (75 cases, treated with lactic acid bacteria vaginal capsules) and the experimental group (75 cases, treated with silk fibroin gel dressings). The clinical therapeutic effects, levels of inflammatory factors, HPV negative conversion status and vaginal microecological conditions (vaginal pH value, Nugent score) of the two groups were compared and evaluated. Results The levels of various inflammatory factors in the experimental group were all lower than those in the control group (P < 0.05). The vaginal pH value and Nugent score of the patients in the experimental group were both lower than those in the control group (P < 0.05). The HPV negative conversion rate and the effective rate of clinical treatment in the experimental group were both higher than those in the control group (P < 0.05). Conclusion The application of silk fibroin gel dressings in the treatment of patients with high-risk human papillomavirus infection complicated with gynecological inflammation has achieved remarkable results. It can significantly increase the HPV negative conversion rate of patients, reduce inflammatory responses, improve vaginal microecology, and has high clinical application value.
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