Research progress on pathological mechanism of acupuncture and moxibustion intervention in tumor related complications
针灸干预肿瘤相关并发症的病理机制研究进展

摘要

本文系统综述近十年针灸干预肿瘤相关并发症的病理机制研究进展。通过梳理40项临床研究，从神经-内分泌-免疫网络调节、炎症因子平衡、氧化应激调控等分子机制层面，结合围手术期胃肠功能维护、放化疗毒副反应控制、癌性疼痛管理、抑郁状态改善等临床应用维度，揭示针灸多靶点、多途径的干预特性。现有证据表明针灸通过调节IL-6、TNF-α等炎性因子水平，上调CD4+/CD8+等免疫指标，改善5-HT、NE等神经递质表达，在肿瘤综合治疗中发挥独特优势，但研究仍存在机制解析深度不足、标准化方案缺失等问题。

Abstract

This paper systematically reviews the research progress on the pathological mechanism of acupuncture and moxibustion intervention in tumor related complications in the past decade. Through sorting out 40 clinical studies, from the molecular mechanism level of neuroendocrine immune network regulation, inflammatory factor balance, oxidative stress regulation, combined with clinical application dimensions such as perioperative gastrointestinal function maintenance, radiation and chemotherapy toxicity control, cancerous pain management, depression improvement, etc., the multi target and multi-channel intervention characteristics of acupuncture and moxibustion are revealed. The existing evidence shows that acupuncture and moxibustion plays a unique advantage in the comprehensive treatment of tumors by regulating the levels of inflammatory factors such as IL-6, TNF - α, up regulating immune indicators such as CD4+/CD8+, improving the expression of neurotransmitters such as 5-HT, NE, etc., but there are still problems such as insufficient depth of mechanism analysis and lack of standardized schemes in the research.