International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (8) ; 10.12208/j.ijcr.20250368 .
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1 首都医科大学宣武医院 北京
2 天津长轻营养食疗科技有限公司 天津
*通讯作者： 李缨,单位： 首都医科大学宣武医院 北京；
目的 初步探究“4816营养食疗体系”在超重/肥胖、2型糖尿病、高脂血症患者中的短期干预效果。方法 本研究为一项单组干预研究，纳入2024年3月至12月期间于长轻营养食疗中心接受系统性饮食干预的48例患有超重/肥胖、2型糖尿病、高脂血症任一疾病的患者。所有患者完成为期12周的分阶段饮食干预，饮食干预包括限时进食（16:8模式）、高膳食纤维饮食、低血糖生成指数饮食、中等碳水化合物供能比饮食、能量限制饮食、间歇性断食（5:2轻断食）、抗炎饮食及益生元强化。于基线、第5周和第12周分别测量体重、体质指数（BMI）、空腹血糖（FBG）、糖化血红蛋白（HbA1c）、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）。比较患者干预前后的各项指标变化。结果 所有受试者均完成至少5周的干预，其中31例（64.6%）完成了为期12周的完整干预方案。干预后患者的BMI、FBG、TC、TG、LDL-C水平显著下降（P<0.05）。结论 12周“4816营养食疗体系”干预可显著改善超重/肥胖、2型糖尿病或高脂血症患者的体重以及血糖、血脂代谢指标，为以上慢性病的膳食干预提供了新的策略。
Objective To preliminarily investigate the short-term effects of the “4816 Nutritional Therapy System” in patients with overweight/obesity, type 2 diabetes, or hyperlipidemia. Methods This was a single-arm interventional study involving 48 patients diagnosed with at least one of the following conditions—overweight/obesity, type 2 diabetes, or hyperlipidemia—who received systematic dietary intervention at the Changqing Nutritional Therapy Center from March to December 2024. All participants completed a 12-week phased dietary intervention incorporating various components: time-restricted eating (16:8 protocol), high dietary fiber diet, low glycemic index (GI) diet, moderate carbohydrate energy ratio diet, energy-restricted diet, intermittent fasting (5:2 protocol), anti-inflammatory diet, and prebiotic fortification. Body weight, Body mass index (BMI) , fasting blood glucose (FBG) , glycated hemoglobin (HbA 1c ), total cholesterol (TC) , triglycerides (TG) , low-density lipoprotein cholesterol ( LDL-C ), and high-density lipoprotein cholesterol (HDL-C) were measured at baseline, week 5, and week 12. Changes in these indicators before and after the intervention were analyzed. Results All participants completed at least 5 weeks of intervention, with 31 cases (64 .6%) completing the full 12-week intervention protocol. After the intervention, participants showed significant reductions in BMI, FBG, HbA 1c, TC, TG, and LDL-C levels (P < 0.05). Conclusion A 12- week intervention using the “4816 Nutritional Therapy System” significantly improved body weight and glycemic and lipid metabolic parameters in patients with overweight/obesity, type 2 diabetes, or hyperlipidemia. These findings suggest a potential new dietary strategy for the management of these chronic conditions.
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