International Journal of Clinical Research
International Journal of Clinical Research. 2025; 9: (7) ; 10.12208/j.ijcr.20250326 .
总浏览量: 47
1 汕头大学医学院 广东深圳
2 深圳市龙华区中心医院 广东深圳
3 深圳市龙岗区妇幼保健院 广东深圳
*通讯作者： 程丹玲,单位： 深圳市龙岗区妇幼保健院 广东深圳；
早产作为妊娠常见并发症，是导致围产儿及5岁以下婴幼儿死亡和残疾的主要原因之一。而其中自发性早产大约占早产病例的2/3，其病理机制涉及多因素、多系统相互作用，具有显著的临床特异性和预测复杂性。因此，识别哪些便捷、精准且无创性的早产预测指标和诊断技术至关重要。同时，积极探索并应用适宜的先进统计学方法，构建一个既具备高灵敏度又拥有高特异性的早产预警系统，是产科学领域面临的主要挑战。本综述旨在总结近年有关自发性早产危险因素与临床转化的研究现状，为优化早产防治策略提供理论依据，并为开展个体化产前干预提供转化医学研究思路。
Preterm birth is a common pregnancy complication and a significant cause of mortality and disability among neonates and children under five years old. Spontaneous preterm birth accounts for about two-thirds of all preterm cases, with its pathophysiology involving multiple factors and systems interacting in complex ways, leading to considerable clinical heterogeneity and prediction challenges. Therefore, identifying and establishing convenient, accurate, and non-invasive predictive factors and diagnostic methods for preterm birth, exploring and applying appropriate and advanced statistical methods, and developing high-sensitivity and specificity preterm birth warning mechanisms are challenging areas in obstetrics. This review aims to summarize recent research on risk factors for spontaneous preterm birth and their clinical applications, providing theoretical basis for optimizing preterm birth prevention and treatment strategies, and offering translational medicine research ideas for personalized prenatal interventions.
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