[email protected]

有机化学与合成

Organic Chemistry and Synthesis

您当前位置:首页 > 精选文章

Organic Chemistry and Synthesis. 2025; 1: (1) ; 10.12208/j.ocs.20250001 .

Ethnomedicinal potential of indian coffee plum: Flacourtia Jangomas
印度咖啡李的民族药用潜力:大叶风铃草

作者: Arun Kumar Srivastava1 *, Arundhati Singh2, Vinay Kumar Singh2

1 MGPG 学院动物学系 印度

2 DDU戈勒克布尔大学动物学系 印度

*通讯作者: Arun Kumar Srivastava,单位: MGPG 学院动物学系 印度;

引用本文: Arun Kumar Srivastava, Arundhati Singh, Vinay Kumar Singh 印度咖啡李的民族药用潜力:大叶风铃草[J]. 有机化学与合成, 2025; 1: (1) : 1-6.
Published: 2025/6/12 14:00:04

摘要

药用植物是重要的本土药物来源,几个世纪以来一直被用于治疗各种疾病。人们正日益从药用植物中分离出生物活性化合物,并将其作为药物研发的重要原料来源。大叶风铃草是一种生长于世界各地的 大黄科 科植物。F . 詹戈马斯的俗名包括咖啡李、印度李、马尼拉樱桃和帕尼拉李。该植物的地上部分用于治疗糖尿病、哮喘、贫血,并具有抗菌、止泻和抗氧化作用。F . 詹戈马斯含有多种生物活性成分,包括碳水化合物、蛋白质、脂质、生物碱、糖苷、单宁等。其果实富含营养成分,包括蛋白质、脂肪、糖、氨基酸、维生素 C 以及钙、钾、磷、铁、镁、钠、锰、铜和锌等矿物质。成熟的果实纤维含量高,蛋白质含量高,脂肪含量低,单不饱和脂肪酸含量高于多不饱和脂肪酸。它含有大量的β-胡萝卜素,其次是叶黄素、玉米黄质、视黄醇和叶绿醌,这些物质对调节人体血红蛋白和纤维蛋白原至关重要。大黄科植物含有种类繁多的化合物,包括萜类化合物、生物碱、黄酮类化合物和单宁、木脂素和黄烷木脂素、糖苷、香豆素和异香豆素。

关键词: 大黄科;抗氧化剂;生物碱;叶绿醌;香豆素

Abstract

Medicinal plants are large-scale sources of indigenous medicines and they have been used for centuries to treat various diseases. Bioactive compounds are being isolated from medicinal plants day by day and serve as an important source of raw materials for drug discovery. Flacourtia jangomas is a plant belonging to the family of Flacourtiaceae growing in various parts of the world. Common names of F. jangomas are Coffee plum, Indian plum, Manila cherry, and Paniala. Aerial parts of the plant are used in the treatment of diabetics, asthma, anemia, and antibacterial, antidiarrheal, and antioxidant activities. F. jangomas revealed several bioactive constituents, including carbohydrates, protein, lipids, alkaloids, glycosides, tannins, etc. The fruits are rich in nutrients, protein, fat, sugars, amino acids, vitamin C, and minerals including calcium, potassium, phosphorous, iron, magnesium, sodium, manganese, copper, and zinc. The ripe fruits have high fiber content together with good protein content, low fat, and higher amount of monounsaturated fatty acids as compared to polyunsaturated fatty acids. It contains a significant amount of beta-carotene followed by lutein and zeaxanthin, retinol, and phylloquinone which are important in the regulation of hemoglobin and fibrinogen in the human body. Flacourtiaceae family elaborates a diverse array of compound classes which include terpenoids, alkaloids, flavonoids and tannins, lignans and flavanolignans, glucosides, coumarins, and isocoumarins.

Key words: Flacourtiaceae; Antioxidant; Alkaloids; Phylloquinone; Coumarins

参考文献 References

[1] Kumar, M.P., Anisha, S., Dhrisya, C., Becky, R., Sadhasivam, S (2021). Therapeutic and pharmacological efficacy of selective Indian medicinal plants – A review. Phytomedicine Plus. 1(2): 100029.

[2] Yu, M., Gouvinhas, I., Rocha, J., Barros, A.I.R.N. (2021). Phytochemical and antioxidant analysis of medicinal and food plants towards bioactive food and pharmaceutical resources. Sci Rep. 11: 10041. 

[3] Atanasov, A.G., Zotchev, S.B., Dirsch, V.M., Supuran, C.T. (2021). Natural products in drug discovery: advances and opportunities. Nat Rev Drug Discov. 20: 200-216.

[4] The wealth of India. (1956). A dictionary of Indian raw materials and industrial products. Raw material, Vol-4: F-G, Council of scientific and industrial research new Delhi, 1956.

[5] Rai, A and Mishra, T. (2020). Ethnomedicinal and therapeutic values of Flacourtia jangomas. The Journal of Indian Botanical Society. 100 (3&4):42-52.

[6] Das, S., Dewan, N., Das, K.J., Kalita, D. (2017). Preliminary phytochemical, antioxidant and antimicrobial studies of  Flacourtia jangomas fruits. Int J Curr Pharm Res. 9(4): 86-91.

[7] Srivastava, D., Prabhu, S.K., Rao, G.P. (2009). Taxonomic and ethno-biological status of Flacourtia jungomas (Lour.) Raeus: An endemic nutraceutical plant of Eastern U.P. Medicinal Plants - International Journal of Phytomedicines and Related Industries. 1(1):49.

[8] Sasi, S., Anjum, N., Tripathi, Y.C. (2018). Ethnomedicinal, Phytochemical and Pharmacological Aspects of Flacourtia jangomas: A Review. Int J Pharm Pharm Sci. 10(3): 9-15.

[9] Mishra, T and Rai, A. (2020). A critical review of Flacourtia jangomas (lour.) Raeusch: a rare fruit tree of Gorakhpur division. European Journal of Biomedical and Pharmaceutical sciences. European Journal of Biomedical AND Pharmaceutical sciences. 7(10): 333-338.

[10] Patro, S.K., Behera, P., Kumar, P.M., Sasmal, D., Padhy, R.K., Dash, S.K. (2013). Pharmacological Review of Flacourtia sepiaria (Ruxb.). Sch. Acad. J. Pharm. 2(2):89-93.

[11] Shrinet, K., Singh, R.K., Chaurasia, A.K., Tripathi, A., Kumar, A. (2021). Chapter 17 - Bioactive compounds and their future therapeutic applications. Natural Bioactive Compounds Technological Advancements. 337-362.

[12] Sabri, G., Vimala, Y. (2018). Antimicrobial activity and Antioxidant activity of Flacourtia jangomas stem from Bihar, India. Journal of Microbiology and Biomedical Research. 4(1):1-6.

[13] Shukla, S., Naik, G., Mishra, S.K. (2015). Potential antimicrobial activity of bacterial endophytes isolated from Flacourtia jangomas (Lour.) Raeusch, a less explored medicinal plant. J Microbiol Biotech Food Sci. 4 (6): 473-477.

[14] Sarker, G.C., Zahan, R., Alam, B.M., Islam, M.D.S., Mosaddik, M.A., Haque, M.E.K (2011). Antibacterial activity of Flacourtia jangomas and Flacourtia sepiaria, Int J of Pharm & Life Sci. 2(7):878-883.

[15] Parvin, S., Kader, A., Sarkar, G.C., Hosain, S.B. (2011). In-vitro studies of antibacterial and cytotoxic properties of Flacourtia jangomas. International J of Pharmaceutical Science and Research. 2(11): 2786-2790. 

[16] George SA, Harini B.P and Bhadran S. In vitro assessment of antifungal activity of selected botanicals on Candida tropicalis. International Journal of Recent Scientific Research, 2016; 7(4) 9863-9866.

[17] Singh, A.K., Singh, J., George, M., Joseph, L. (2010). Anti-diabetic effect of Flacourtia jangomas extract in alloxan-induced diabetic rats. Pharmacology. 2: 253-259.

[18] Sindhu, K., Sujith, S., Shynu, M., Rani, S.S., Juliet, S., Nair, D. (2018). Anti-hyperglycemic activity of methanolic extract of Flacourtia montana in streptozotocin induced diabetic rats. The Pharma Innovation Journal. 7(7): 22-27.

[19] Joshy, C., Thahimon, P.A. (2016). Kumar, R.A., Carla, B., Sunil, C. Hepatoprotective, anti-inflammatory and antioxidant activities of Flacourtia montana J. Grah leaf extract in male Wistar rats. Bulletin of Faculty of Pharmacy, Cairo University. 54(2): 209-217. 

[20] Barua, U., Das, R.P., Das, P., Das, K., Gogoi, B. (2022). Morpho-physiological, proximate composition and antioxidant activity of Flacourtia jangomas (Lour.) Raeus. Indian Society for Plant Physiology. 1-9.

[21] Talukder, C., Saha, S., Adhikari, S., Mondal, H.K., Islam, M.K., Anisuman, M. (2012). Evaluation of antioxidant, analgesic and antidiarrhoeal activity of Flacourtia jangomas (lour.) Raeusch. leaves. Pharmacology Archives. 3: 20-28.

[22] Mutha, R.E., Tatiya, A.U., Surana, S.J. (2021). Flavonoids as natural phenolic compounds and their role in therapeutics: an overview. Futur J Pharm Sci. 7(1):25. 

[23] Rahman, M.M., Habib, M.R., Hasan, M.R., Islam, M.T., Khan, I.N. (2012). Comparative antioxidant potential of different extracts of Flacourtia jangomas lour fruits. Asian J Pharm Clin Res. 5(1): 73-75.

[24] Jothimanivannan, C., Lalitha, P., Meena, K., Meenajesiliya, A., Moganapriya, J.C., Manimekalai, P. (2021). An investigation of the analgesic and anti-inflammatory effects of aerial parts of Flacourtia jangomas. Int J Pharm Pharm Sci. 13(7): 77-81.

[25] Islam, M.A.F., Masuma, R., Rahman, A.M.R., Hossain, M.S., Hasan, M.N., Jubayer, A. (2022). Evaluation of analgesic, anti-inflammatory and antipyretic properties of the Flacourtia indica extract in laboratory animal. J. Phytomol. Pharmacol. 1(2), 66-74.

[26] George, S.A., Bhadran, S., Sudhakar, M., Harini, B.P. (2017). Comprehensive in vitro evaluation of pharmacological activities of selected plant extracts and gas chromatography-mass spectrometry profiling of Flacourtia jangomas flower extract. Asian J Pharm Clin Res. 10(5): 237-244.

[27] Mouna, R., Broisat, A., Ahmed, A., Debiossat, M., Boumendjel, A., Ghezzi, C., Kabouche. (2022). Antiproliferative activity, cell-cycle arrest, apoptotic induction and LC-HRMS/MS analyses of extracts from two Linum species. Pharmaceutical Biology. 60(1): 1491-1501.

[28] Aklima, J., Mojumder, S., Sikdar, D. (2014). Total phenolic content, reducing power, antioxidative and anti-amylase activities of five Bangladeshi fruits. International Food Research Journal. 21(1): 119-124.

[29] Sarkar, D., Christopher, A., Shetty, K. (2022). Phenolic bio-actives from plant-based foods for glycemic control. Front. Endocrinol. 12:727503.