International Medical Research Frontier
International Medical Research Frontier. 2024; 8: (2) ; 10.12208/j.imrf.20240017 .
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广西医科大学 广西南宁
*通讯作者： 王蕊,单位：广西医科大学 广西南宁；
炎症反应与心血管疾病的关联机制已成为现代医学研究的核心领域。研究表明，炎症反应通过促进动脉粥样硬化斑块形成、心肌损伤及心室重构等病理过程，与心血管疾病的发生发展密切相关。C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）等炎症标志物不仅可作为疾病风险的独立预测因子，还在心肌梗死、心力衰竭的早期诊断和预后评估中发挥关键作用。在治疗策略上，抗炎药物如IL-1β抑制剂（Canakinumab）和靶向炎症通路的综合管理方案已通过临床试验验证其疗效，显著降低心血管事件风险。未来研究将聚焦于炎症标志物的精准阈值界定、多组学技术驱动的生物标志物发现，以及个体化抗炎治疗策略的优化。
The association mechanism between inflammatory response and cardiovascular disease has become a core area of modern medical research. Studies have shown that inflammatory response is closely related to the occurrence and development of cardiovascular disease by promoting pathological processes such as atherosclerotic plaque formation, myocardial injury and ventricular remodeling. Inflammatory markers such as C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) can not only serve as independent predictors of disease risk, but also play a key role in the early diagnosis and prognosis evaluation of myocardial infarction and heart failure. In terms of treatment strategies, anti-inflammatory drugs such as IL-1β inhibitors (Canakinumab) and comprehensive management programs targeting inflammatory pathways have been verified through clinical trials to significantly reduce the risk of cardiovascular events. Future research will focus on the precise threshold definition of inflammatory markers, biomarker discovery driven by multi-omics technology, and the optimization of individualized anti-inflammatory treatment strategies.
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