Clinical study of afentanil and sufentanil combined with propofol in painless gastroenteroscopy
阿芬太尼或舒芬太尼联合丙泊酚用于无痛胃肠镜中的临床效果研究

摘要

目的 观察阿芬太尼联合丙泊酚在无痛胃肠镜检查中的临床效果，为更安全合理的应用提供依据。方法 选取2022年3月至2024年2月接受无痛胃肠镜检查的200名患者，随机分为丙泊酚联合阿芬太尼组（PA组）和丙泊酚联合舒芬太尼组（PS组），每组100人。记录术后恢复时间、生命体征、丙泊酚用量、镇静评分及不良事件，评估满意度。结果 PA组苏醒和恢复室停留时间显著短于PS组（P＜0.05）；诱导后1min、3min时PA组心率高于PS组（P＜0.05）。PS组诱导时间、低血压发生率和多巴胺用量高于PA组（P＜0.05）；血氧饱和度在某些时点有差异但均在95%以上。PA组患者和麻醉医生满意度显著高于PS组（P＜0.05）。结论 阿芬太尼联合丙泊酚在无痛胃肠镜检查中相较于舒芬太尼具有更快的苏醒、更稳定的循环系统和更少的不良反应，提高了满意度。

Abstract

Objective To observe the clinical effect of alfentanil combined with propofol in painless gastrointestinal endoscopy and provide basis for safer and more reasonable application.
Methods 200 patients who underwent painless gastrointestinal endoscopy from March 2022 to February 2024 were selected and randomly divided into the propofol combined with alfentanil group (PA group) and the propofol combined with sufentanil group. (PS group), 100 people in each group. Postoperative recovery time, vital signs, propofol dosage, sedation score and adverse events were recorded to evaluate satisfaction.
Results The recovery and recovery room stay time of the PA group was significantly shorter than that of the PS group (P＜0.05); the heart rate of the PA group was higher than that of the PS group at 1 and 3 minutes after induction (P＜0.05). The induction time, incidence of hypotension and dopamine dosage in the PS group were higher than those in the PA group (P＜0.05); blood oxygen saturation was different at certain time points but was all above 95%. The patient and anesthesiologist satisfaction in the PA group was significantly higher than that in the PS group (P＜0.05).
Conclusion   Compared with sufentanil, alfentanil combined with propofol has faster recovery, more stable circulatory system and fewer adverse reactions in painless gastrointestinal endoscopy, which improves satisfaction.